Evidence map›Paper›PMID 27989461›Full record

ArticleNeuron2017

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons.

Yael Mandelblat-Cerf, Angela Kim, Christian R Burgess, Siva Subramanian, Bakhos A Tannous, Bradford B Lowell, Mark L Andermann

Abstract read
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 100 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. InducibleAmerican journal of physiology. Renal physiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Dysregulation of the fluid homeostasis system by aging.bioRxiv : the preprint server for biology · 2024
    Article
  13. Fluid transitions.Neuropharmacology · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Review
  19. Thirst: neuroendocrine regulation in mammals.Veterinary research communications · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yael Mandelblat-CerfDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Angela KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Christian R BurgessDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Siva SubramanianDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Bakhos A TannousProgram in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: blowell@bidmc.harvard.edu.
Mark L AndermannDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: manderma@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · USMassachusetts General Hospital · US

Funding

Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Interdepartmental Neuroscience CenterP30NS045776 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, TANNOUS, BAKHOS A · 2003 to 2018
$11.1M
The routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1M
AGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2M
Neurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0M
Multiphoton Imaging of Thoughts of Food During Natural and Induced Hunger StatesDP2DK105570 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2014 to 2014
$2.5M
Neural Pathway Linking Nutritional State To Food-Cue Responses In Insular CortexR01DK109930 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2016 to 2020
$2.2M
NIDDK NIH HHS DP2 DK105570NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK109930NINDS NIH HHS P30 NS045776
6 · The paper itself

Abstract

Ingestion of water and food are major hypo- and hyperosmotic challenges. To protect the body from osmotic stress, posterior pituitary-projecting, vasopressin-secreting neurons (VP

Indexed as

Osmotic PressureAnimalsArginine VasopressinCuesDrinking BehaviorFeeding BehaviorMiceNeuronsOsmolar ConcentrationSupraoptic NucleusVasopressinsArginine VasopressinVasopressinsElectrophysiologyFiber PhotometryFood and water cuesFood restrictionNeuroendocrine neuronPlasma osmolalityPosterior pituitaryPreingestivePresystemicSupraoptic nucleusVasopressin

Identifiers

PMID27989461
PMCPMC5215952
OpenAlexW2563689244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.