Evidence map›Paper›PMID 27989442›Full record

ArticleMolecular cell2017

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication.

Joseph T P Yeeles, Agnieska Janska, Anne Early, John F X Diffley

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

248 citing papers in PubMed, 370 citations in OpenAlex.

  1. Article
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  4. Article
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  9. Mitotic kinase regulation of DNA replication forks.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Dynamic Assemblies in Genome Maintenance.Advances in experimental medicine and biology · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Structure of the human CTF18-RFC clamp loader bound to PCNA.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph T P YeelesThe Francis Crick Institute, Clare Hall Laboratory, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
Agnieska JanskaThe Francis Crick Institute, Clare Hall Laboratory, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
Anne EarlyThe Francis Crick Institute, Clare Hall Laboratory, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
John F X DiffleyThe Francis Crick Institute, Clare Hall Laboratory, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK. Electronic address: john.diffley@crick.ac.uk.
The Francis Crick Institute · GB

Funding

Cancer Research UK 15669Wellcome Trust
6 · The paper itself

Abstract

The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to copy the leading- and lagging-strand templates at rates between 1 and 2 kb min

Indexed as

DNA ReplicationCell Cycle ProteinsDNA, FungalDNA Polymerase IIDNA Polymerase IIIProliferating Cell Nuclear AntigenSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTime FactorsCell Cycle ProteinsCsm3p protein, S cerevisiaeDNA, FungalDNA Polymerase IIDNA Polymerase IIIMRC1 protein, S cerevisiaePOL30 protein, S cerevisiaeProliferating Cell Nuclear AntigenSaccharomyces cerevisiae Proteins

Identifiers

PMID27989442
PMCPMC5222725
OpenAlexW2562393208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.