Evidence map›Paper›PMID 27989323›Full record

ArticleAmerican journal of human genetics2017

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Aalto, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 383 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
383citing papers in PubMed, 10 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

383 citing papers in PubMed, 10 syntheses or guidelines pooled it, 655 citations in OpenAlex.

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  17. Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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323 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 2 countries.

Ari V Ahola-OlliResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland. Electronic address: avahol@utu.fi.
Peter WürtzComputational Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.
Aki S HavulinnaNational Institute of Health and Welfare, 00271 Helsinki, Finland.
Kristiina AaltoMedicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
Terho LehtimäkiThe Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, 33014 Tampere, Finland.
Mika KähönenThe Department of Clinical Physiology, Tampere University Hospital, 33521 Tampere, Finland.
Leo-Pekka LyytikäinenThe Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, 33014 Tampere, Finland.
Emma RaitoharjuThe Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, 33014 Tampere, Finland.
Ilkka SeppäläThe Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, 33014 Tampere, Finland.
Antti-Pekka SarinNational Institute of Health and Welfare, 00271 Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Samuli RipattiNational Institute of Health and Welfare, 00271 Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; The Department of Public Health, University of Helsinki, 00271 Helsinki, Finland.
Aarne PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Markus PerolaNational Institute of Health and Welfare, 00271 Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Jorma S ViikariThe Department of Medicine, University of Turku, 20520 Turku, Finland; Division of Medicine, Turku University Hospital, 20520 Turku, Finland.
Sirpa JalkanenMedicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
Mikael MaksimowMedicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
Veikko SalomaaNational Institute of Health and Welfare, 00271 Helsinki, Finland.
Marko SalmiMedicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
Johannes KettunenComputational Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland; National Institute of Health and Welfare, 00271 Helsinki, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland; Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland; Biocenter Oulu, University of Oulu, 90014 Oulu, Finland; The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20520 Turku, Finland.
University of Turku · FIPirkanmaa Hospital District · FIUniversity of Helsinki · FIFinnish Institute for Health and Welfare · FIBroad Institute · USTampere University Hospital · FIUniversity of Eastern Finland · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10

Indexed as

Genome-Wide Association StudyAutoimmune DiseasesColitis, UlcerativeCrohn DiseaseCytokinesFemaleHumansInflammationIntercellular Signaling Peptides and ProteinsMaleMultiple SclerosisQuantitative Trait LociCytokinesIntercellular Signaling Peptides and Proteins

Identifiers

PMID27989323
PMCPMC5223028
OpenAlexW2566908060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.