Evidence map›Paper›PMID 27989269›Full record

ArticleFood & nutrition research2016

Dietary tryptophan depletion in humans using a simplified two amino acid formula - a pilot study.

Maike Linden, Katrin Helmbold, Janina Kempf, Shabnam Sippas, Christian Filss, Karl-Josef Langen, Albrecht Eisert, Florian Daniel Zepf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food & nutrition research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Maike LindenClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Katrin HelmboldClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Janina KempfClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Shabnam SippasClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Christian FilssSection JARA-Brain, Jülich-Aachen Research Alliance (JARA), Jülich, Germany.
Karl-Josef LangenSection JARA-Brain, Jülich-Aachen Research Alliance (JARA), Jülich, Germany.
Albrecht EisertDepartment of Pharmacy, RWTH Aachen University, Aachen, Germany.
Florian Daniel ZepfClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
RWTH Aachen University · DEMaastricht University · NLGovernment of Western Australia Department of Health · AUJülich Aachen Research Alliance · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute tryptophan depletion (ATD) is a well-established dietary method in translational brain research used to briefly lower central nervous serotonin (5-hydroxytryptamine (5-HT)) synthesis. A simplified two amino acid ATD formula (ATD

objectiveThis study investigated tryptophan (TRP) influx rates across the blood-brain barrier (BBB) after dietary ATD

designSeventy-two healthy adults (50% females) were randomized into four groups and administered ATD Moja-De, its TRP-balanced control condition (BAL), ATD

resultsBoth challenge mixtures significantly reduced central nervous TRP influx as calculated by Michaelis-Menten kinetics relative to baseline and the respective control conditions with only mild and comparable side effects. A greater decline in TRP influx over the BBB after ATD

conclusionsThis pilot study provides preliminary evidence for the possibility of lowering TRP influx as calculated by Michaelis-Menten kinetics into the brain by using a simplified ATD protocol in humans. The simplified composition of only two AAs, the lower overall AA amount, and the appropriate tolerance are characteristics of the newly developed ATD

Indexed as

amino acidsdietary tryptophan depletionhumansinflux rateMichaelis–Menten kineticsserotonin

Identifiers

PMID27989269
PMCPMC5165058
OpenAlexW2567081643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.