Evidence map›Paper›PMID 27989136›Full record

ArticleChemical research in toxicology2016

Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress.

Carlos Morales Betanzos, Joel D Federspiel, Amy M Palubinsky, BethAnn McLaughlin, Daniel C Liebler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. PGAM5 Modulates Macrophage Polarization, Aggravating Inflammation in COPD via the NF-κB Pathway.International journal of chronic obstructive pulmonary disease · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carlos Morales BetanzosDepartment of Biochemistry, Vanderbilt University School of Medicine, ‡Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, §Department of Neurology, Vanderbilt University , Nashville, Tennessee 37232, United States.
Joel D FederspielDepartment of Biochemistry, Vanderbilt University School of Medicine, ‡Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, §Department of Neurology, Vanderbilt University , Nashville, Tennessee 37232, United States.
Amy M PalubinskyDepartment of Biochemistry, Vanderbilt University School of Medicine, ‡Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, §Department of Neurology, Vanderbilt University , Nashville, Tennessee 37232, United States.
BethAnn McLaughlinDepartment of Biochemistry, Vanderbilt University School of Medicine, ‡Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, §Department of Neurology, Vanderbilt University , Nashville, Tennessee 37232, United States.
Daniel C LieblerDepartment of Biochemistry, Vanderbilt University School of Medicine, ‡Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, §Department of Neurology, Vanderbilt University , Nashville, Tennessee 37232, United States.ORCID 0000-0002-7873-3031
Vanderbilt University · US

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
ASK signalosomes and environmental sensingR01ES022936 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCLAUGHLIN, BETHANN M · 2014 to 2018
$1.8M
NIEHS NIH HHS R01 ES022936NIEHS NIH HHS T32 ES007028
6 · The paper itself

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a critical cellular stress sensor that senses diverse reactive chemotypes and integrates these chemical signals into a single biological pathway response. It is unknown whether ASK1 senses all stressors in the same way or if unique stress-specific mechanisms detect distinct chemotypes. In order to answer this question, we treated ASK1-expressing cells with two distinct stress activators, H

Indexed as

Oxidative StressAmino Acid SequenceChromatography, LiquidHEK293 CellsHumansMAP Kinase Kinase Kinase 5PhosphorylationSequence Homology, Amino AcidTandem Mass SpectrometryMAP3K5 protein, humanMAP Kinase Kinase Kinase 5

Identifiers

PMID27989136
PMCPMC5937698
OpenAlexW2555069220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.