Evidence map›Paper›PMID 27989109›Full record

ArticleACS applied materials & interfaces2017

Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity.

Cartney E Smith, JuYeon Lee, Yongbeom Seo, Nicholas Clay, Jooyeon Park, Artem Shkumatov, Dawn Ernenwein, Mei-Hsiu Lai, Sanjay Misra, Charles E Sing and 3 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Iron Oxide Nanoparticles as TAdvanced materials (Deerfield Beach, Fla.) · 2021
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cartney E SmithDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
JuYeon LeeDepartment of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Yongbeom SeoDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Nicholas ClayDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.ORCID http://orcid.org/0000-0002-0343-8812
Jooyeon ParkDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Artem ShkumatovDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Dawn ErnenweinDepartment of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Mei-Hsiu LaiDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.ORCID http://orcid.org/0000-0002-4456-556X
Sanjay MisraDepartment of Radiology, Mayo Clinic , Rochester, Minnesota 55905, United States.
Charles E SingDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.ORCID http://orcid.org/0000-0001-7231-2685
Brenda AndradeDepartment of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Steven C ZimmermanDepartment of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Hyunjoon KongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.ORCID http://orcid.org/0000-0003-4680-2968

Funding

The Role of Hypoxia In Venous Neointimal Hyperplasia In Hemodialysis GraftsR01HL098967 · NHLBI · MAYO CLINIC ROCHESTER · PI Sanjay Misra · 2010 to 2026
$10.4M
Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Nanocells for vascular normalization therapiesR01HL109192 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2011 to 2015
$1.9M
NHLBI NIH HHS R01 HL098967NHLBI NIH HHS R01 HL109192NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

Nanosized bioprobes that can highlight diseased tissue can be powerful diagnostic tools. However, a major unmet need is a tool with adequate adhesive properties and contrast-to-dose ratio. To this end, this study demonstrates that targeted superparamagnetic nanoprobes engineered to present a worm-like shape and hydrophilic packaging enhance both adhesion efficiency to target substrates and magnetic resonance (MR) sensitivity. These nanoprobes were prepared by the controlled self-assembly of superparamagnetic iron oxide nanoparticles (SPIONs) into worm-like superstructures using glycogen-like amphiphilic hyperbranched polyglycerols functionalized with peptides capable of binding to defective vasculature. The resulting worm-like SPION clusters presented binding affinity to the target substrate 10-fold higher than that of spherical ones and T

Indexed as

Magnetite NanoparticlesContrast MediaHydrophobic and Hydrophilic InteractionsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyContrast MediaMagnetite Nanoparticleshyperbranched polyglycerolmagnetic resonance imagingnonspherical nanoparticle clustersuperparamagnetic iron oxide nanoparticletargeted imaging

Identifiers

PMID27989109
PMCPMC10977606

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.