Evidence map›Paper›PMID 27988981›Full record

Trial reportClinical transplantation2017

Gender differences in long-term survival post-transplant: A single-institution analysis in the lung allocation score era.

Gabriel Loor, Roland Brown, Rosemary F Kelly, Kyle D Rudser, Sara J Shumway, Irena Cich, Christopher T Holley, Colleen Quinlan, Marshall I Hertz

Abstract readClinical Trial
In one paragraph

Trial report in Clinical transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The role of coronary artery disease in lung transplantation: a propensity-matched analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The intersection of race and ethnicity, gender, and primary diagnosis on lung transplantation outcomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  11. Twenty-year survival following lung transplantation.Journal of thoracic disease · 2023
    Article
  12. Article
  13. Article
  14. Disparities in heart and lung transplantation.Current opinion in organ transplantation · 2021
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriel LoorUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Roland BrownUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Rosemary F KellyUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Kyle D RudserUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Sara J ShumwayUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Irena CichUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Christopher T HolleyUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Colleen QuinlanUniversity of Minnesota Department of Surgery, Minneapolis, MN, USA.
Marshall I HertzUniversity of Minnesota Department of Medicine, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

The purpose of this study was to clarify the significance of recipient gender status on lung transplant outcomes in a large single-institution experience spanning three decades, we analyzed data from all lung transplants performed in our institution since 1986. Kaplan-Meier curves and Cox proportional hazard models were used to evaluate the effect of recipient characteristics on survival and BOS score ≥1-free survival. Logistic regression analysis was used to explore the association of gender with short-term graft function. About 876 lung transplants were performed between 1986 and 2016. Kaplan-Meier survival estimates at 5 years post-transplant for females vs males in the LAS era were 71% vs 58%. In the LAS era, females showed greater unadjusted BOS≥1-free survival than males (35% vs 25%, P=.02) over 5 years. Female gender was the only factor in the LAS era significantly associated with improved adjusted 5-year survival [HR 0.56 (95% CI 0.33, 0.95) P=.03]. Conversely, in the pre-LAS era female gender was not associated with improved survival. Female recipients showed significantly improved survival over 5 years compared to males in the LAS era. A prospective analysis of biologic and immunologic differences is warranted.

Indexed as

Tissue and Organ ProcurementAdultFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansLung DiseasesLung TransplantationMaleMiddle AgedPostoperative ComplicationsPrognosisRetrospective StudiesRisk FactorsSex Factorsbronchiolitis obliterans syndromeclinical outcomesgenderlung transplantprimary graft dysfunctionrecipient factors

Identifiers

PMID27988981
PMCPMC5336403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.