Evidence map›Paper›PMID 27988804›Full record

Trial reportPediatric nephrology (Berlin, Germany)2017

Monosymptomatic nocturnal enuresis in pediatric patients: multidisciplinary assessment and effects of therapeutic intervention.

Simone N Fagundes, Adrienne Surri Lebl, Leticia Azevedo Soster, Guilherme Jorge Sousa E Silva, Edwiges Ferreira de Mattos Silvares, Vera H Koch

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Desmopressin for nocturnal enuresis in children.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Alarm interventions for nocturnal enuresis in children.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Pooled it
  5. Review
  6. Article
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  10. SunCloud: A mobile application for children with urinary incontinence.Journal of evaluation in clinical practice · 2025
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Simone N FagundesDepartment of Pediatrics - Instituto da Criança, University of São Paulo Medical School, São Paulo, Brazil. sifagun@terra.com.br.
Adrienne Surri LeblDepartment of Pediatrics - Instituto da Criança, University of São Paulo Medical School, São Paulo, Brazil.
Leticia Azevedo SosterPediatric Sleep Laboratory, Instituto da Criança Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
Guilherme Jorge Sousa E SilvaDepartment of Pediatrics - Instituto da Criança, University of São Paulo Medical School, São Paulo, Brazil.
Edwiges Ferreira de Mattos SilvaresClinical Psychology Department of São Paulo University, São Paulo, Brazil.
Vera H KochDepartment of Pediatrics - Instituto da Criança, University of São Paulo Medical School, São Paulo, Brazil.
Universidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies manage patients with isolated monosymptomatic enuresis (MNE) with multidisciplinary evaluation and pre- and long-term post-intervention monitoring.

methodsThis was a prospective study of MNE patients, aged 6-16 years, diagnosed by multidisciplinary assessment. Of the 140 initial applicants (58.6%) with MNE, 82 were included in the study and randomized for therapeutic intervention in three treatment groups, namely: alarm, desmopressin and alarm + desmopressin. Therapeutic response was evaluated 12 months after treatment withdrawal.

resultsOf the 82 patients [mean age 9.5 (SD ± 2.6) years, n = 62 males (75.6%)], 91.1% had a family history of nocturnal enuresis (NE) in first-/second-degree relatives, 81.7% had constipation and 40.7% had mild-to-moderate apnea. Prior to randomization, management of constipation and urotherapy led to remission in seven of the 82 patients; 75 patients were randomized to intervention. There were 14/75 (18.7%) dropouts during the intervention, especially in the alarm group (p = 0.00). Initial complete/partial response was achieved in 56.6% of the alarm group, 70% of the desmopressin group and 64% in the combined group (p = 0.26). Continued success occurred in 70% of the alarm group, 84.2% of the desmopressin group and 100% of the combined group (p = 0.21). Recurrence occurred in 3/20 (15%) patients in the alarm group and 1/19 (5.2 %) patients of the desmopressin group. Post-intervention Child Behavior Checklist (CBCL) and PedsQL 4.0 scores showed significant improvement.

conclusionsThe three therapeutic modalities were effective in managing MNE with low relapse rates; the alarm group showed the highest dropout rate. Therapeutic success was associated with improvement of behavioral problems and quality of life scores.

Indexed as

Patient Care TeamAdolescentChildChild BehaviorChild, PreschoolClinical AlarmsCombined Modality TherapyConstipationDeamino Arginine VasopressinDisease ManagementFemaleHumansMaleNocturnal EnuresisPatient DropoutsProspective StudiesDeamino Arginine VasopressinRenal AgentsAdolescentsAlarmChildrenDesmopressinNocturnal monosymptomatic enuresisTreatment

Identifiers

PMID27988804
OpenAlexW2561579816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.