Evidence map›Paper›PMID 27988413›Full record

ArticlePsychiatry research. Neuroimaging2017

White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study.

Johanna Seitz, Amanda E Lyall, Gen Kanayama, Nikos Makris, James I Hudson, Marek Kubicki, Harrison G Pope, Marc J Kaufman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Nandrolone Decanoate: Use, Abuse and Side Effects.Medicina (Kaunas, Lithuania) · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Public health impact of androgens.Current opinion in endocrinology, diabetes, and obesity · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Johanna SeitzPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gen KanayamaBiological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nikos MakrisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Departments of Psychiatry, Neurology and Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
James I HudsonBiological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marek KubickiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Departments of Psychiatry, Neurology and Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harrison G PopeBiological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc J KaufmanMcLean Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill St., Belmont 02478, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: kaufman@mclean.harvard.edu.
Harvard University · USMcLean Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · USBrigham and Women's Hospital · USMassachusetts General Hospital · US

Funding

Stuart T. Hauser Research Training Program in Biological and Social Psychiatry.T32MH016259 · NIMH · JUDGE BAKER CHILDREN'S CENTER · PI Marek Kubicki, Martha E. Shenton · 1985 to 2026
$8.4M
Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie RestrictionRF1AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7M
Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0M
Diffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8M
Medical Consequences of Long-Term Anabolic-Androgenic Steroid AbuseR01DA029141 · NIDA · MCLEAN HOSPITAL · PI POPE, HARRISON G · 2011 to 2015
$2.5M
Mentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945k
NIA NIH HHS R01 AG042512NIA NIH HHS R01 AG043640NIA NIH HHS RF1 AG043640NIDA NIH HHS R01 DA029141NIMH NIH HHS K24 MH110807NIMH NIH HHS R01 MH102377NIMH NIH HHS T32 MH016259
6 · The paper itself

Abstract

Recent studies of long-term anabolic-androgenic steroid (AAS) users reported amygdala structural and functional connectivity abnormalities. We assessed white matter microstructure in the inferior-fronto-occipital fasciculus (IFOF), a major associative bundle of the amygdala network. Diffusion weighted images acquired from 9 male long-term AAS users and 8 matched controls aged 36-51 years old were processed using a standardized pipeline (Tract-Based Spatial Statistics). Group differences were examined using linear regression with adjustment for age and current testosterone level. Compared to nonusers, AAS users exhibited significantly higher fractional anisotropy (FA) in the IFOF. Users showed markedly greater FA than nonusers on the left IFOF but only a modest, nonsignificant difference on the right IFOF. Moreover, FA was positively associated with lifetime cumulative AAS dose. Our results suggest that long-term AAS use alters IFOF white matter organization and integrity, which in turn might affect amygdala-related processes such as reward system function. Accordingly, further studies are needed to replicate findings in larger subject groups to determine the functional significance of the FA abnormality.

Indexed as

AdultAndrogensAnisotropyBrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansMaleMiddle AgedPilot ProjectsTestosterone CongenersWhite MatterAndrogensTestosterone Congeners(4): Diffusion tensor imaging (DTI)Anabolic-androgenic steroids (AAS)Inferior-fronto-occipital fasciculus (IFOF)Tract-based spatial statistics (TBSS)

Identifiers

PMID27988413
PMCPMC5272808
OpenAlexW2560179099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.