ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2017
A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Human white matter myelinates faster in utero than ex utero.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gestational and postnatal age associations for striatal tissue iron deposition in early infancy.bioRxiv : the preprint server for biology · 2023Article
- Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study.BMC medicine · 2023Article
- Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans.Obesity (Silver Spring, Md.) · 2022Article
- Diffusion Tensor Based White Matter Tract Atlases for Pediatric Populations.Frontiers in neuroscience · 2022Article
- Prospective association of maternal psychosocial stress in pregnancy with newborn hippocampal volume and implications for infant social-emotional development.Neurobiology of stress · 2021Article
- Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity.Social cognitive and affective neuroscience · 2020Article
- Article
- Exploring early human brain development with structural and physiological neuroimaging.NeuroImage · 2019Review
- Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life.NeuroImage · 2019Article
- Neonatal White Matter Maturation Is Associated With Infant Language Development.Frontiers in human neuroscience · 2019Article
- Mapping White Matter Microstructure in the One Month Human Brain.Scientific reports · 2017Article
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Abstract
Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth=39.1±1.6 weeks [GA], postnatal age at scan=25.5±12.2days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MI
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