Evidence map›Paper›PMID 27988330›Full record

ArticleJournal of psychiatric research2017

The gut microbiome composition associates with bipolar disorder and illness severity.

Simon J Evans, Christine M Bassis, Robert Hein, Shervin Assari, Stephanie A Flowers, Marisa B Kelly, Vince B Young, Vicky E Ellingrod, Melvin G McInnis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 12 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simon J EvansDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United States. Electronic address: evanssi@umich.edu.
Christine M BassisDepartment of Internal Medicine/Infectious Diseases Division, University of Michigan, Ann Arbor, MI, United States.
Robert HeinDepartment of Internal Medicine/Infectious Diseases Division, University of Michigan, Ann Arbor, MI, United States.
Shervin AssariDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United States.
Stephanie A FlowersSchool of Pharmacy, University of Michigan, Ann Arbor, MI, United States.
Marisa B KellyDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United States.
Vince B YoungDepartment of Microbiology & Immunology, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine/Infectious Diseases Division, University of Michigan, Ann Arbor, MI, United States.
Vicky E EllingrodSchool of Pharmacy, University of Michigan, Ann Arbor, MI, United States.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United States.

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jeffrey F Horowitz · 2010 to 2026
$20.3M
Nutritional Components of Psychiatric Disease and Treatment ResponseK01MH093708 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EVANS, SIMON J · 2012 to 2015
$588k
NIDDK NIH HHS P30 DK089503NIMH NIH HHS K01 MH093708
6 · The paper itself

Abstract

The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with burden of disease measures. We compared the stool microbiome from individuals with bipolar disorder (n = 115) and control subjects (n = 64) using 16S ribosomal RNA (rRNA) gene sequence analysis. Analysis of molecular variance (AMOVA) revealed global community case-control differences (AMOVA p = 0.047). Operational Taxonomical Unit (OTU) level analysis revealed significantly decreased fractional representation (p < 0.001) of Faecalibacterium after adjustment for age, sex, BMI and false discovery rate (FDR) correction at the p < 0.05 level. Within individuals with bipolar disorder, the fractional representation of Faecalibacterium associated with better self-reported health outcomes based on the Short Form Health Survey (SF12); the Patient Health Questionnaire (PHQ9); the Pittsburg Sleep Quality Index (PSQI); the Generalized Anxiety Disorder scale (GAD7); and the Altman Mania Rating Scale (ASRM), independent of covariates. This study provides the first detailed analysis of the gut microbiome relationships with multiple psychiatric domains from a bipolar population. The data support the hypothesis that targeting the microbiome may be an effective treatment paradigm for bipolar disorder.

Indexed as

AdultAnalysis of VarianceBipolar DisorderFecesFemaleGastrointestinal MicrobiomeGastrointestinal TractHumansLongitudinal StudiesMaleMiddle AgedPsychiatric Status Rating ScalesRegression AnalysisRNA, Ribosomal, 16SSurveys and QuestionnairesRNA, Ribosomal, 16SBipolar disorderFaecalibacteriumGeneralized Anxiety Disorder scaleMicrobiomePatient Health QuestionnairePittsburg Sleep Quality Index

Identifiers

PMID27988330
PMCPMC5336480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.