Evidence map›Paper›PMID 27988096›Full record

ArticleTrends in parasitology2017

Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target.

Anyango D Kamina, Noreen Williams

Abstract readComment
In one paragraph

Article in Trends in parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anyango D KaminaDepartment of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA.
Noreen WilliamsDepartment of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA. Electronic address: nw1@buffalo.edu.

Funding

Ribosomal biogenesis in trypanosomesR01GM110227 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2014 to 2017
$1.2M
Targeting the trypanosomal preribosomal complexR01GM113890 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM110227NIGMS NIH HHS R01 GM113890
6 · The paper itself

Abstract

In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.

Indexed as

Drug DiscoveryAntiprotozoal AgentsDrug Delivery SystemsProtein MultimerizationRibosomesTrypanosomatinaTrypanosomiasisAntiprotozoal Agentsribosome assemblyribosome structure.rRNA processingtrypanosomatids

Identifiers

PMID27988096
PMCPMC5376504

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.