ArticleItalian journal of pediatrics2016
Vitamin D deficiency and its impact on asthma severity in asthmatic children.
Article in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The serum level of vitamin D and prevalence of vitamin D deficiency among children with asthma in Asia and Africa: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2024Pooled it
- The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- An Investigation of Vitamin Levels Status in the Serum of Children in China.BioMed research international · 2018Trial
- [Observation and analysis of Vitamin D levels in 147 children undergoing adenoidectomy and/or tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Vitamin D exerts endogenous control over TiScience · 2025Article
- Serum Vitamin D Profiles of Children with Asthma in Southwest Saudi: A Comparative Cross-Sectional Study.International journal of general medicine · 2024Article
- The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.Biomedicines · 2023Article
- Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study.BMC pulmonary medicine · 2023Article
- Stunting as a Risk Factor for Asthma: The Role of Vitamin D, Leptin, IL-4, and CD23.Medicina (Kaunas, Lithuania) · 2022Review
- Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives.Journal of immunology research · 2022Review
- The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection.Clinical and molecular allergy : CMA · 2021Review
- Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study.NPJ primary care respiratory medicine · 2021Article
- Body Mass Index and C-reactive Protein Are Potential Predictors of Asthma Development in Egyptian Polycystic Ovary Syndrome Patients.Journal of medical biochemistry · 2019Article
- Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).Molecular and cellular pediatrics · 2019Article
- Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.Italian journal of pediatrics · 2017Review
- Impact of Vitamin D Receptor Genotypes on Taiwan Asthma Risk.In vivo (Athens, Greece)Article
- Pediatric Asthma Control: A Focus on Vitamin D Serum Levels in Moroccan Children.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite obtaining evidences on association between vitamin D and development of lung in fetus, little is known about vitamin D level and its impact on severity of asthma in children. The present study aimed to assess the relationship between the asthma severity and vitamin D deficiency in asthmatic children.
methodsThis case-control study was conducted on 106 individuals including asthmatic (n = 53) and healthy children (n = 53) who referred to Mofid hospital in Tehran in 2013. The level of serum vitamin D in both groups was measured by radioimmunoassay method at the reference lab and was categorized as sufficient (> 30 ng/ml), insufficient (20 to 30 ng/ml), or deficient (< 20 ng/ml). The control status of asthma in patients group was classified as controlled, partially controlled, and uncontrolled.
resultsIn the groups with and without asthma, the prevalence of vitamin D deficiency was 73.6 and 49.1%, and the prevalence of vitamin D insufficiency was 18.9 and 18.9%, while normal vitamin D level was revealed in 7.5 and 32.1%, respectively with a significant difference (p = 0.005). Using the multivariate logistic regression analysis, the presence of asthma was associated with reduced level of vitamin D (OR = 1.068, 95% CI: 1.027-1.110, P = 0.001). In this context, the risk for asthma in the children with vitamin D deficiency was 6.3 times of those with normal vitamin D level. Although the presence of asthma was strongly associated with reduced level of vitamin D in serum, neither severity of asthma nor control status of asthma were associated with vitamin D deficiency.
conclusionThe presence of vitamin D deficiency effectively predict increased risk for childhood asthma; however the severity or control status of this event may not be predicted by confirming vitamin D deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.