Evidence map›Paper›PMID 27987368›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2017

Postnatal systemic inflammation and neuro-ophthalmologic dysfunctions in extremely low gestational age children.

Mari Holm, Dordi Austeng, Raina N Fichorova, Elizabeth N Allred, Karl C Kuban, T Michael O'Shea, Olaf Dammann, Alan Leviton, ELGAN Study Investigators

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Mari HolmDepartment of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0003-3968-0851
Dordi AustengDepartment of Neuroscience (INM), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Raina N FichorovaDepartment of Obstetrics, Gynecology, and Reproductive Biology, Laboratory of Genital Tract Biology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Elizabeth N AllredNeuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA.
Karl C KubanDivision of Pediatric Neurology, Department of Pediatrics, Boston University, Boston, MA, USA.
T Michael O'SheaDivision of Neonatology, Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Olaf DammannDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Alan LevitonNeuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA.
ELGAN Study Investigators
Boston Children's Hospital · USNorwegian University of Science and Technology · NOBoston University · USBrigham and Women's Hospital · USTufts University · USWake Forest University · US

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Circulating Immune Biomarkers and Retinopathy of PrematurityR01EY021820 · NEI · TUFTS UNIVERSITY BOSTON · PI DAMMANN, OLAF · 2013 to 2016
$1.7M
NEI NIH HHS R01 EY021820NICHD NIH HHS P30 HD018655NICHD NIH HHS U54 HD090255NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

aimCompared to infants born at term, children born very preterm are at increased risk of visual dysfunctions and neonatal systemic inflammation. Here, we explore whether these two propensities are related.

methodsAs part of the ELGAN study, the concentrations of 16 mediators of inflammation were measured in blood obtained on postnatal days 1, 7, 14, 21 and 28 from 1062 children born before the 28th week of gestation. Presence of visual field deficit, strabismus and/or impaired visual fixation was recorded at age two. The concentrations of each protein were divided into quartiles within gestational week categories. We calculated odds ratios with 99% confidence intervals for having each disorder comparing children with concentration in the top quartile of each protein to children whose concentration was in the lower quartiles on the corresponding day. Analyses were adjusted for gestational age and birth weight Z-score.

resultsOnly one of 80 assessments (16 proteins on five different days) was significant for visual field deficit, and one for impaired fixation. No association was found between strabismus and any inflammatory mediator.

conclusionNone of the three neuro-ophthalmologic dysfunctions assessed at two years appears to be associated with systemic inflammation measured the first four postnatal weeks.

Indexed as

BiomarkersHumansInfant, Extremely PrematureInfant, NewbornInflammationStrabismusVision DisordersVisual FieldsBiomarkersInflammationPrematurityStrabismusVisual developmentVisual impairment

Identifiers

PMID27987368
PMCPMC5303161
OpenAlexW2564158909

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.