Evidence map›Paper›PMID 27987300›Full record

ReviewJournal of biomechanical engineering2017

Implantable Sensors for Regenerative Medicine.

Brett S Klosterhoff, Melissa Tsang, Didi She, Keat Ghee Ong, Mark G Allen, Nick J Willett, Robert E Guldberg

Abstract readReview
In one paragraph

Review in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. A piezoelectric bone fixation plate forMeasurement science & technology · 2020
    Article
  7. Wireless Technologies for Implantable Devices.Sensors (Basel, Switzerland) · 2020
    Review
  8. Article
  9. Article
  10. Impact of industry 4.0 to create advancements in orthopaedics.Journal of clinical orthopaedics and trauma · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Electrical Interconnects Fabricated From Biodegradable Conductive Polymer Composites.IEEE transactions on components, packaging, and manufacturing technology · 2019
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brett S KlosterhoffGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332;Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332.
Melissa TsangSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Didi SheDepartment of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Keat Ghee OngDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931.
Mark G AllenSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332;Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Nick J WillettParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332;Department of Orthopaedics, Emory University, Atlanta, GA 30303;Atlanta Veteran's Affairs Medical Center, Decatur, GA 30033;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.
Robert E GuldbergGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332;Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332.

Funding

Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
Regenerative Rehabilitation of Complex Musculoskeletal InjuriesR01AR069297 · NIAMS · UNIVERSITY OF OREGON · PI ROBERT E Guldberg · 2016 to 2026
$5.6M
In Vivo Monitoring of Strain and Oxygen in TE Constructs Using MEMS-Based SensorsR21AR066322 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GULDBERG, ROBERT E · 2015 to 2016
$368k
NIAMS NIH HHS R01 AR069297NIAMS NIH HHS R21 AR066322NIGMS NIH HHS T32 GM008433
6 · The paper itself

Abstract

The translation of many tissue engineering/regenerative medicine (TE/RM) therapies that demonstrate promise in vitro are delayed or abandoned due to reduced and inconsistent efficacy when implemented in more complex and clinically relevant preclinical in vivo models. Determining mechanistic reasons for impaired treatment efficacy is challenging after a regenerative therapy is implanted due to technical limitations in longitudinally measuring the progression of key environmental cues in vivo. The ability to acquire real-time measurements of environmental parameters of interest including strain, pressure, pH, temperature, oxygen tension, and specific biomarkers within the regenerative niche in situ would significantly enhance the information available to tissue engineers to monitor and evaluate mechanisms of functional healing or lack thereof. Continued advancements in material and fabrication technologies utilized by microelectromechanical systems (MEMSs) and the unique physical characteristics of passive magnetoelastic sensor platforms have created an opportunity to implant small, flexible, low-power sensors into preclinical in vivo models, and quantitatively measure environmental cues throughout healing. In this perspective article, we discuss the need for longitudinal measurements in TE/RM research, technical progress in MEMS and magnetoelastic approaches to implantable sensors, the potential application of implantable sensors to benefit preclinical TE/RM research, and the future directions of collaborative efforts at the intersection of these two important fields.

Indexed as

Prostheses and ImplantsTransducersBiosensing TechniquesEquipment DesignEquipment Failure AnalysisGuided Tissue RegenerationMicro-Electrical-Mechanical SystemsRegenerative Medicine

Identifiers

PMID27987300
PMCPMC5253675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.