Evidence map›Paper›PMID 27987070›Full record

ArticlePharmaceutical research2017

Local Radiation Treatment of HER2-Positive Breast Cancer Using Trastuzumab-Modified Gold Nanoparticles Labeled with

Zhongli Cai, Simmyung Yook, Yijie Lu, Dane Bergstrom, Mitchell A Winnik, Jean-Philippe Pignol, Raymond M Reilly

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  4. Small science · 2025
    Review
  5. In Vitro Assessment ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Therapeutic potential of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Zhongli CaiDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.
Simmyung YookDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.
Yijie LuDepartment of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada.
Dane BergstromDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.
Mitchell A WinnikDepartment of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada.
Jean-Philippe PignolDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Raymond M ReillyDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, M5S 3M2, Canada. raymond.reilly@utoronto.ca.
University of Toronto · CAErasmus MC Cancer Institute · NLKeimyung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the effectiveness of trastuzumab-modified gold nanoparticles (AuNP) labeled with

methodsAuNP (30 nm) were modified with polyethylene glycol (PEG) polymers linked to trastuzumab or to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelators to complex

resultsTrastuzumab-AuNP-

conclusionTrastuzumab-AuNP-

Indexed as

AnimalsAntineoplastic Agents, ImmunologicalBreast NeoplasmsCell Line, TumorCell SurvivalCoordination ComplexesErb-b2 Receptor Tyrosine KinasesFemaleGoldHumansIndium RadioisotopesLutetiumMetal NanoparticlesMiceMice, Inbred NODMice, SCIDAntineoplastic Agents, ImmunologicalCoordination ComplexesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGoldIndium RadioisotopesLutetiumPolyethylene GlycolsRadiopharmaceuticalsTrastuzumabbreast cancergold nanoparticlesHER2intratumoral injectionlutetium-177

Identifiers

PMID27987070
OpenAlexW2562574147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.