ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Bone marrow sFRP5 level is negatively associated with bone formation markers.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 23 citations in OpenAlex.
- Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications.Angiogenesis · 2025Review
- Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS).Bone reports · 2025Review
- Optimizing bone health for the prevention of revision adult spinal deformity surgery: a break-even analysis.Spine deformity · 2025Article
- Research Progress on the Mechanism of the SFRP-Mediated Wnt Signalling Pathway Involved in Bone Metabolism in Osteoporosis.Molecular biotechnology · 2024Review
- A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint.NPJ systems biology and applications · 2023Article
- From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Populations: Decreased Bone Turnover Bioactivity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.Journal of nanobiotechnology · 2021Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Secreted frizzled-related protein 5 (sFRP5) level in bone marrow environment is inversely correlated with bone formation markers, suggesting that it decreases bone mass by inhibiting bone formation. Besides, it functions in a local fashion when regulating bone metabolism. sFRP5 may be a target when developing anti-osteoporotic agents.
introductionThe purpose of the study is to investigate the relationship between bone marrow sFRP5 level and bone turnover state.
methodsEighty-three total knee arthroplasty patients were enrolled in this study. Data were collected prospectively and reviewed retrospectively. Lumbar spine and femoral neck bone mineral density (BMD), marrow adipose tissue (MAT) sFRP5 messenger RNA (mRNA) expression level, sFRP5 concentrations in marrow fluid and serum, concentrations of bone formation and resorption markers were measured for each participant.
resultsMarrow fluid sFRP5 concentration was positively correlated with both MAT sFRP5 expression (p = 0.040) and serum sFRP5 concentration (p = 0.043). Significantly positive correlation existed between MAT sFRP5 expression level and BMD (p < 0.05). Marrow fluid sFRP5 concentration had a moderate but not significant positive association with BMD. MAT sFRP5 was negatively related to serum bone formation markers including N-terminal propeptide of type 1 procollagen (P1NP) (p = 0.011), osteocalcin (OC), and alkaline phosphatase (ALP). Marrow fluid and serum sFRP5 concentrations also had mild negative correlations with bone formation markers but reached no significance. There was no significant correlation between bone resorption marker β-crosslaps (β-CTX) and sFRP5. The mRNA expression level of MAT sFRP5 was positively related with those of MAT leptin, peroxisome proliferator-activated receptor-γ (PPARγ), and adiponectin, and its correlation with leptin was statistically significant (p = 0.026).
conclusionsBone marrow sFRP5 level is closely correlated with BMD and bone formation markers. sFRP5 may be a potential negative regulator of bone mass by inhibiting bone formation. It may exert its effects on bone metabolism in a paracrine, rather than endocrine manner.
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