Evidence map›Paper›PMID 27986973›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.

Emilie I Petit, Zuzanna Michalak, Rachel Cox, Colm M P O'Tuathaigh, Niamh Clarke, Orna Tighe, Konrad Talbot, Derek Blake, Josephine Joel, Alexander Shaw and 8 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Dysbindin-1 Involvement in the Etiology of Schizophrenia.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Emilie I PetitMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Zuzanna MichalakDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Rachel CoxMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Colm M P O'TuathaighMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Niamh ClarkeMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Orna TigheMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Konrad TalbotDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA, USA.
Derek BlakeInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-5005-4731
Josephine JoelNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Alexander ShawNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Steven A SheardownNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Alastair D MorrisonNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Stephen WilsonNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Ellen M ShaplandNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
David C HenshallDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.
James N KewNeurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Brian P KirbySchool of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland.
John L WaddingtonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.

Funding

Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

Dysbindin-1, a protein that regulates aspects of early and late brain development, has been implicated in the pathobiology of schizophrenia. As the functional roles of the three major isoforms of dysbindin-1, (A, B, and C) remain unknown, we generated a novel mutant mouse, dys-1A

Indexed as

AnimalsAttentionBehavior, AnimalDisease Models, AnimalDysbindinFemaleMaleMemory, Long-TermMemory, Short-TermMiceMice, TransgenicOlfactory PerceptionPhenotypeProtein IsoformsSchizophreniaDtnbp1 protein, mouseDysbindinProtein Isoforms

Identifiers

PMID27986973
PMCPMC5437891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.