Evidence map›Paper›PMID 27986908›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination.

Zhaoyou Meng, Ting Zhao, Kai Zhou, Qi Zhong, Yanchun Wang, Xiaoyi Xiong, Faxiang Wang, Yuanrui Yang, Wenyao Zhu, Juan Liu and 10 more

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pathogenic Functions of Tumor Necrosis Factor Receptor-Frontiers in molecular neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Zhaoyou MengDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Ting ZhaoDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Kai ZhouDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Qi ZhongDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Yanchun WangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Xiaoyi XiongDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Faxiang WangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Yuanrui YangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Wenyao ZhuDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Juan LiuDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Maofan LiaoDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Lirong WuDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Chunmei DuanDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Jie LiDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Qiuwen GongDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Liang LiuDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Ao XiongBasic Medical College, Zhengzhou University, Zhengzhou 450000, China; and.
Meihua YangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Jian WangDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Qingwu YangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; yangqwmlys@hotmail.com.ORCID 0000-0001-8540-6488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reducing excessive inflammation is beneficial for the recovery from intracerebral hemorrhage (ICH). Here, the roles and mechanisms of A20 (TNFAIP3), an important endogenous anti-inflammatory factor, are examined in ICH. A20 expression in the PBMCs of ICH patients and an ICH mouse model was detected, and the correlation between A20 expression and neurologic deficits was analyzed. A20 expression was increased in PBMCs and was negatively related to the modified Rankin Scale score. A20 expression was also increased in mouse perihematomal tissues. A20

Indexed as

AdultAgedAnimalsApoptosisBlotting, WesternCerebral HemorrhageElectrophoretic Mobility Shift AssayFemaleFluorescent Antibody TechniqueGene Knockdown TechniquesHumansImmunoprecipitationInflammationMaleMiceMice, Inbred C57BLTNF Receptor-Associated Factor 6Tumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID27986908
PMCPMC5220121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.