ArticleRNA (New York, N.Y.)2017
Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.
Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Differences in Peripheral Blood Gene Expression of Xinjiang Brown Cattle with Varying Somatic Cell Counts.Biology · 2026Article
- Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data.Discover oncology · 2025Article
- Targeted splicing therapy: new strategies for colorectal cancer.Frontiers in oncology · 2023Review
- OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer.Molecular biology reports · 2022Article
- A Novel miRNA Located in theBioMed research international · 2022Article
- Article
- Skeletal muscle transcriptome in healthy aging.Nature communications · 2021Article
- LOC646329 long non-coding RNA sponges miR-29b-1 and regulates TGFβ signaling in colorectal cancer.Journal of cancer research and clinical oncology · 2020Article
- Long Noncoding RNA LOC400043 (LINC02381) Inhibits Gastric Cancer Progression Through Regulating Wnt Signaling Pathway.Frontiers in oncology · 2020Article
- Hsa-miR-335 regulates cardiac mesoderm and progenitor cell differentiation.Stem cell research & therapy · 2019Article
- Overexpressed in colorectal carcinoma gene (OCC-1) upregulation and APPL2 gene downregulation in breast cancer specimens.Molecular biology reports · 2018Article
- COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix.Scientific reports · 2018Article
- Identification of a novel intergenic miRNA located between the human DDC and COBL genes with a potential function in cell cycle arrest.Molecular and cellular biochemistry · 2018Article
- Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.Nucleic acids research · 2018Article
- The expression and significance of microRNA in different stages of colorectal cancer.Medicine · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt signaling pathway is hyperactivated in most colorectal cancers (CRC). Finding new regulators of this pathway represents the potential for cancer diagnosis or treatment. OCC-1 was initially reported as an up-regulated gene in colon carcinoma, without knowing its mechanism of action. Here, two novel transcript variants and an exonic microRNA that originated from the OCC-1 gene are reported, showing positive effects on Wnt activity. Up-regulation of the known OCC-1 variant (assigned as OCC-1A/B) was limited to CRC, and its overexpression increased survival of CRC-originated SW480 cells (Wnt
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