ArticleJournal of leukocyte biology2017
Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS.
Abstract read
In one paragraph
Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- Role of HIV-1 in IL-8 response of human stellate cells to gram-positive microbial products.Scientific reports · 2026Article
- Hepatic Viral Reservoirs in Concurrent HIV and HBV: From Mechanistic Insight to Integrated Cure Strategies.Infection and drug resistance · 2026Review
- Biliary atresia: Rotavirus amplification of lipopolysaccharide/toll-like receptor 4 by mediating MMP7 upregulation through NF-κB.Pediatric research · 2025Article
- Hepatitis B surface antigen is upregulated by HIV Tat in an HIV-hepatitis B virus co-infection model system.Microbiology spectrum · 2025Article
- The role of liver macrophages in viral liver pathogenesis.Journal of leukocyte biology · 2025Review
- A historical perspective of Kupffer cells in the context of infection.Cell and tissue research · 2025Review
- Innate immune memory in chronic HIV and HIV-associated neurocognitive disorders (HAND): potential mechanisms and clinical implications.Journal of neurovirology · 2024Review
- Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection.Open forum infectious diseases · 2024Article
- Review
- Risk Stratification of Advanced Fibrosis in Patients With Human Immunodeficiency Virus and Hepatic Steatosis Using the Fibrosis-4, Nonalcoholic Fatty Liver Disease Fibrosis, and BARD Scores.Open forum infectious diseases · 2024Article
- Risk Stratification of Advanced Fibrosis in HIV Patients With Hepatic Steatosis Using the NAFLD Fibrosis and BARD Scores.medRxiv : the preprint server for health sciences · 2023Article
- Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy.JCI insight · 2022Article
- HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages.PLoS pathogens · 2022Article
- Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients - a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown.Frontiers in endocrinology · 2022Review
- Infections at the nexus of metabolic-associated fatty liver disease.Archives of toxicology · 2021Review
- Altered expression of fractalkine in HIV-1-infected astrocytes and consequences for the virus-related neurotoxicity.Journal of neurovirology · 2021Article
- Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR.Journal of virology · 2021Article
- Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind.Cancers · 2021Review
- A Tale of Two Viruses: Immunological Insights Into HCV/HIV Coinfection.Frontiers in immunology · 2021Review
- Microbiota-Meditated Immunity Abnormalities Facilitate Hepatitis B Virus Co-Infection in People Living With HIV: A Review.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Arevik MosoianDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lumin ZhangDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Feng HongDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Francesc CunyatUniversity of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Adeeb RahmanDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Riti BhallaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ankur PanchalDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yedidya SaimanDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
M Isabel FielDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sander FlormanDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sasan RoayaieRecanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; and.
Myron SchwartzRecanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; and.
Andrea BranchDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mario StevensonUniversity of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Meena B BansalDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; meena.bansal@mssm.edu.
Icahn School of Medicine at Mount Sinai · USUniversity of Miami · US
Funding
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007792 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CHO, JUDY H. · 2001 to 2016
$2.3MHIV and hepatic inflammation and fibrosisR01DK108364 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BANSAL, MEENA B · 2015 to 2019
$1.1MStellate cell-HIV interactions and Hepatic FibrosisR56DK092128 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BANSAL, MEENA B · 2011 to 2011
$368kNIDDK NIH HHS R01 DK108364NIDDK NIH HHS R56 DK092128NIDDK NIH HHS T32 DK007792
Abstract
End-stage liver disease is a common cause of non-AIDS-related mortality in HIV
Indexed as
Host-Pathogen InteractionsAnimalsCD4-Positive T-LymphocytesEnd Stage Liver DiseaseGene Expression RegulationHIV-1HIV InfectionsHumansInterleukin-6Kupffer CellsLipopolysaccharide ReceptorsLipopolysaccharidesLiver CirrhosisPrimary Cell CultureSignal TransductionSulfonamidesethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateIL6 protein, humanInterleukin-6Lipopolysaccharide ReceptorsLipopolysaccharidesSulfonamidesTLR4 protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphaHIV-induced hepatic inflammationliver fibrosismicrobial translocation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.