ArticleHuman reproduction (Oxford, England)2017
The slow growing embryo and premature progesterone elevation: compounding factors for embryo-endometrial asynchrony.
Article in Human reproduction (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation.Human reproduction (Oxford, England) · 2021Pooled it
- Day 5 versus Day 6 blastocyst transfers: a systematic review and meta-analysis of clinical outcomes.Human reproduction (Oxford, England) · 2019Pooled it
- Luteal-phase stimulation does not compromise embryo euploidy or live birth outcomes compared to follicular-phase stimulation.Frontiers in medicine · 2026Article
- Evaluating the effect of simple follicular cysts on clinical pregnancy outcomes in in-vitro fertilization cycles.Archives of gynecology and obstetrics · 2025Article
- An analysis of freeze-all cycles to investigate the association between elevated progesterone on day of trigger and oocyte quality.Journal of assisted reproduction and genetics · 2025Article
- Establishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure.Journal of assisted reproduction and genetics · 2025Article
- Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes.Frontiers in endocrinology · 2025Article
- Paternal undernutrition and overnutrition modify semen composition and preimplantation embryo developmental kinetics in mice.BMC biology · 2024Article
- Progestin Primed Ovarian Stimulation (PPOS) protocol yields lower euploidy rate in older patients undergoing IVF.Reproductive biology and endocrinology : RB&E · 2023Article
- Delayed blastocyst development is influenced by the level of progesterone on the day of trigger.Journal of assisted reproduction and genetics · 2023Article
- Effect modification by developmental stage of embryos on the association between late follicular phase progesterone elevation and live birth in fresh transfers.BMC pregnancy and childbirth · 2023Article
- Effects of trigger-day progesterone in the preimplantation genetic testing cycle on the embryo quality and pregnancy outcomes of the subsequent first frozen-thawed blastocyst transfer.Frontiers in endocrinology · 2023Article
- The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles.Journal of clinical medicine · 2022Article
- Review
- Use of a new set of key performance indicators for evaluating the performance of anThe Journal of international medical research · 2021Article
- Elevated serum progesterone does not impact euploidy rates in PGT-A patients.Journal of assisted reproduction and genetics · 2021Article
- Progesterone levels on the human chorionic gonadotropin trigger day affect the pregnancy rates for embryos transferred at different stages of development in both general and selected IVF/ICSI populations.BMC pregnancy and childbirth · 2021Article
- EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third- versus second-generation estradiol and progesterone immunoassays.Journal of endocrinological investigation · 2020Article
- Effect of the time for embryo transfer from oocyte retrieval on clinical outcomes in freeze-all cycles: a retrospective cohort study.Archives of gynecology and obstetrics · 2020Article
- Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome.Journal of assisted reproduction and genetics · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
study questionIs there an association of progesterone (P SUMMARY ANSWER: P WHAT IS KNOWN ALREADY: Premature P STUDY DESIGN SIZE, DURATION: This was a retrospective cohort study with autologous IVF cycles with fresh embryo transfers on day 5 and day 6 from 2011 to 2014. A total of 4120 day 5 and 230 day 6 fresh autologous embryo transfers were included. The primary outcome was live birth, defined as a live born baby at 24 weeks gestation or later. PARTICIPANTS/MATERIALS, SETTING,
methodsPatients from a large private ART practice were included. Analysis was performed with generalized estimating equations (GEE) modeling and receiver operating characteristic (ROC) curves. MAIN RESULTS AND THE ROLE OF CHANCE: Day 6 transfers were less likely to have good quality embryos (73% versus 83%, P < 0.001) but the cohorts had similar rates of blastocyst stage transfer (92% versus 91%, P = 0.92). Live birth was less likely in fresh day 6 versus day 5 embryo transfers (34% versus 46%, P = 0.01) even when controlling for embryo confounders. In adjusted GEE models, the effect of P LIMITATIONS REASONS FOR CAUTION: Limitations include the retrospective design and the inability to control for certain confounding variables, such as thaw survival rates between day 5 and day 6 blastocysts. Also, the data set lacks the known ploidy status of the embryos and the progesterone assay is not currently optimized to discriminate between patients with a P WIDER IMPLICATIONS OF THE
findingsThis study suggests further endometrial-embryo asynchrony when a slow growing embryo is combined with an advanced endometrium, ultimately leading to decreased live births. This suggests that premature elevated P STUDY FUNDING/COMPETING INTERESTS: No external funding was received for this study. There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER: Not applicable.
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