ArticleThe Journal of cell biology2017
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 4 pooled it
21.0field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
211 citing papers in PubMed, 4 syntheses or guidelines pooled it, 344 citations in OpenAlex.
- A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration.Frontiers in immunology · 2024Pooled it
- Diagnostic utility of GDF15 in neurodegenerative diseases: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- Accuracy of FGF-21 and GDF-15 for the diagnosis of mitochondrial disorders: A meta-analysis.Annals of clinical and translational neurology · 2020Pooled it
- Association between MIC-1 and Type 2 Diabetes: A Combined Analysis.Disease markers · 2019Pooled it
- Exercise-Based Rehabilitation in Severe COVID-19 Survivors with Long COVID: A Randomized Controlled Pilot Study.Medical sciences (Basel, Switzerland) · 2026Trial
- Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans.Frontiers in endocrinology · 2026Trial
- The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker).Cardiovascular diabetology · 2022Trial
- Effects of Exercise Intervention on Mitochondrial Stress Biomarkers in Metabolic Syndrome Patients: A Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.The Journal of clinical investigation · 2021Trial
- GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement.The Journal of clinical endocrinology and metabolism · 2020Trial
- Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans.JCI insight · 2020Trial
- Context-specific hypermetabolism in humans with mitochondrial defects.Cell press blue · 2026Article
- Association of plasma growth differentiation factor 15 with wake after sleep onset in mild cognitive impairment.The journal of nutrition, health & aging · 2026Article
- A multilayered stress-response circuit: The mammalian mitochondrial UPR.The FEBS journal · 2026Review
- Growth Differentiation Factor 15 and Histology-Defined Steatohepatitis and Fibrosis in Severe Obesity Undergoing Bariatric Surgery.Obesity surgery · 2026Observational
- Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart Failure.International journal of molecular sciences · 2026Review
- p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes.JCI insight · 2026Article
- Reductive Stress and Dysregulated Energy Metabolism in Schizophrenia: Mechanisms and Therapeutic Targets.Biological psychiatry · 2026Review
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging.Science advances · 2026Article
151 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 3 countries.
Hyo Kyun ChungResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0001-6737-8372
Dongryeol RyuLaboratory for Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5905-6760
Koon Soon KimResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0002-5545-2093
Joon Young ChangResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.
Yong Kyung KimResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0001-9841-3695
Hyon-Seung YiResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0002-3767-1954
Seul Gi KangResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0001-7529-8460
Min Jeong ChoiResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.
Seong Eun LeeResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.
Saet-Byel JungResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.ORCID http://orcid.org/0000-0001-5747-087X
Min Jeong RyuResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.
Soung Jung KimResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea.
Gi Ryang KweonDepartment of Biochemistry, Chungnam National University School of Medicine, Daejeon 34134, South Korea.
Hail KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-338, South Korea.ORCID http://orcid.org/0000-0002-6652-1349
Jung Hwan HwangAnimal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-764, South Korea.
Chul-Ho LeeAnimal Model Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-764, South Korea.ORCID http://orcid.org/0000-0002-6996-5746
Se-Jin LeeDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID http://orcid.org/0000-0003-1523-0389
Christopher E WallGene Expression Laboratory, Salk Institute, La Jolla, CA 92037.ORCID http://orcid.org/0000-0002-4059-2042
Michael DownesGene Expression Laboratory, Salk Institute, La Jolla, CA 92037.
Ronald M EvansGene Expression Laboratory, Salk Institute, La Jolla, CA 92037.ORCID http://orcid.org/0000-0002-9986-5965
Johan AuwerxLaboratory for Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland admin.auwerx@epfl.ch minhos@cnu.ac.kr.ORCID http://orcid.org/0000-0002-5065-5393
Minho ShongResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, South Korea admin.auwerx@epfl.ch minhos@cnu.ac.kr.ORCID http://orcid.org/0000-0002-0247-7115
Chungnam National University · KRSalk Institute for Biological Studies · USÉcole Polytechnique Fédérale de Lausanne · CHJohns Hopkins University · USKorea Research Institute of Bioscience and Biotechnology · KRKorea Advanced Institute of Science and Technology · KR
Funding
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MSpatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0MCharacterization of Myostatin and GDF-11R01AR060636 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LEE, SE-JIN · 2010 to 2020
$3.7MHormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6MTranslational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5MMolecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin ResistanceR24DK090962 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 2010 to 2011
$1.5MNHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL105278NIAMS NIH HHS R01 AR060636NIA NIH HHS R01 AG043930NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R24 DK090962NIDDK NIH HHS R37 DK057978NIEHS NIH HHS P42 ES010337
Abstract
Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and -non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPR
Indexed as
Energy Metabolism3T3-L1 CellsAdipose TissueAnimalsCell Cycle ProteinsGenetic Predisposition to DiseaseGrowth Differentiation Factor 15HomeostasisInsulin ResistanceLeptinLipolysisLiverMaleMiceMice, Inbred C57BLMice, KnockoutCell Cycle ProteinsCrif1 protein, mouseDdit3 protein, mouseGDF15 protein, humanGdf15 protein, mouseGrowth Differentiation Factor 15LeptinRecombinant ProteinsTranscription Factor CHOP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.