Evidence map›Paper›PMID 27986757›Full record

ArticleJournal of the American Heart Association2016

Cyanate-Impaired Angiogenesis: Association With Poor Coronary Collateral Growth in Patients With Stable Angina and Chronic Total Occlusion.

Jia Teng Sun, Ke Yang, Jing Yan Mao, Wei Feng Shen, Lin Lu, Qi Hong Wu, Yan Ping Wang, Li Ping Wu, Rui Yan Zhang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04390711 (An Observational Cross-sectional Study to Compare Carbamylated High-density Lipoprotein Levels Among Normal Subjects, Type 2 Diabetes Mellitus Patients With and Without Coronary Heart Disease.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04390711 completednot on this mapstarted 2018, after this paper: background citation

An Observational Cross-sectional Study to Compare Carbamylated High-density Lipoprotein Levels Among Normal Subjects, Type 2 Diabetes Mellitus Patients With and Without Coronary Heart Disease.

TypeobservationalSponsorRenJi HospitalRan2018 to 2019Enrolled282ConditionsType 2 Diabetes Mellitus With Circulatory ComplciationArmsHigh density lipoprotein isolation, detection and in-vitro study.
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Protein carbamylation in end stage renal disease: is there a mortality effect?Current opinion in nephrology and hypertension · 2018
    Review
  6. Mechanisms and consequences of carbamoylation.Nature reviews. Nephrology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jia Teng SunDepartment of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ke YangInstitute of Cardiovascular Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing Yan MaoInstitute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Wei Feng ShenDepartment of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin LuDepartment of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi Hong WuShanghai Key Laboratory of Hypertension and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan Ping WangInstitute of Cardiovascular Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Ping WuInstitute of Cardiovascular Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rui Yan ZhangDepartment of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China rjzhangruiyan@126.com.
Ruijin Hospital · CNShanghai Jiao Tong University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyanate has recently gained attention for its role in the pathogenesis of vascular injury. Nonetheless, the effect of cyanate on angiogenesis remains unclear. METHODS AND

resultsIn this study, we demonstrated that oral administration of cyanate impaired blood perfusion recovery in a mouse hind-limb ischemia model. A reduction in blood perfusion recovery at day 21 was observed in the ischemic tissue of cyanate-treated mice. Likewise, there were fewer capillaries in the ischemic hind-limb tissue of cyanate-exposed mice. Our in vitro study showed that cyanate, together with its carbamylated products, inhibited the migration, proliferation, and tube-formation abilities of endothelial cells. Further research revealed that cyanate regulated angiogenesis partly by interrupting the vascular endothelial growth factor receptor 2/phosphatidylinositol 3-kinase/Akt pathway. The serum concentrations of homocitrulline, a marker of cyanate exposure, were determined in 117 patients with stable angina and chronic total occlusion. Consistent with the antiangiogenic role of cyanate, homocitrulline levels were increased in patients with poor coronary collateralization (n=58) compared with those with high collateralization (n=59; 21.09±13.08 versus 15.54±9.02 ng/mL, P=0.009). In addition, elevated homocitrulline concentration was a strong predictor of poor coronary collateral growth.

conclusionsImpaired angiogenesis induced by cyanate might contribute to poor coronary collateral growth.

Indexed as

Administration, OralAgedAnalysis of VarianceAngina, StableAngiogenesis Inducing AgentsAnimalsCells, CulturedChronic DiseaseCitrullineCollateral CirculationCoronary AngiographyCoronary OcclusionCyanatesEndothelium, VascularFemaleHindlimbAngiogenesis Inducing AgentsCitrullineCyanateshomocitrullineKdr protein, mouseVascular Endothelial Growth Factor Receptor-2angiogenesiscarbamylationchronic total coronary occlusioncollateral circulationcyanateendothelial dysfunction

Identifiers

PMID27986757
PMCPMC5210395
OpenAlexW2561964665

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.