ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Biomarkers Associated With Extranodal Extension (ENE) in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Systematic Review.Head & neck · 2026Pooled it
- Biomarkers predict enhanced clinical outcomes with afatinib versus methotrexate in patients with second-line recurrent and/or metastatic head and neck cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Trial
- HERTHENA-PanTumor01: a phase II study of patritumab deruxtecan (HER3-DXd) in previously treated advanced solid tumors.Future oncology (London, England) · 2025Article
- New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines.Infectious agents and cancer · 2025Article
- Microenvironment-based immunotherapy in oral cancer: a comprehensive review.Medical oncology (Northwood, London, England) · 2025Review
- Crosstalk between CAFs and tumour cells in head and neck cancer.Cell death discovery · 2024Review
- Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives.International journal of molecular sciences · 2024Review
- PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications.Biology · 2023Review
- An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a focus on carcinomas.Cancer biomarkers : section A of Disease markers · 2023Article
- HER3 in cancer: from the bench to the bedside.Journal of experimental & clinical cancer research : CR · 2022Review
- Tumor microenvironment and immunotherapy of oral cancer.European journal of medical research · 2022Review
- Biomarkers and 3D models predicting response to immune checkpoint blockade in head and neck cancer (Review).International journal of oncology · 2022Review
- Diagnostics of HNSCC Patients: An Analysis of Cell Lines and Patient-Derived Xenograft Models for Personalized Therapeutical Medicine.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer.Cell death and differentiation · 2021Article
- Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.Nature communications · 2021Article
- A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPVOncotarget · 2021Article
- Photodynamic and Cold Atmospheric Plasma Combination Therapy Using Polymeric Nanoparticles for the Synergistic Treatment of Cervical Cancer.International journal of molecular sciences · 2021Article
- MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors.PLoS pathogens · 2021Article
- Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review.Frontiers in oncology · 2021Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
14 authors at 1 institution in 1 country.
Toni M BrandDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Stefan HartmannDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Neil E BholaDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Noah D PeyserDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Hua LiDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Yan ZengDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Erin Isaacson WechslerDivision of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California.
Max V RanallHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Sourav BandyopadhyayHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Umamaheswar DuvvuriDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Theresa M LaValleeKolltan Pharmaceuticals, New Haven, Connecticut.
Richard C K JordanDepartments of Orofacial Sciences and Pathology, University of California San Francisco, San Francisco, California.
Daniel E JohnsonDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Jennifer R GrandisDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California. jennifer.grandis@ucsf.edu.
University of Pittsburgh · US
Funding
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4MPI3K Pathway Mutations in Head and Neck CancerR01DE023685 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRANDIS, JENNIFER RUBIN, JOHNSON, DANIEL E · 2014 to 2023
$5.1MGRPR Signaling in SCCHN: Integration with EGFRR01CA098372 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRANDIS, JENNIFER RUBIN · 2004 to 2017
$3.8MInhibition of lysosomal flux in carcinogen-induced head and neck cancerR01DE028343 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUVVURI, UMAMAHESWAR · 2019 to 2023
$1.9MPhysical and Genetic Interaction Landscape of the Tyrosine KinomeR01GM107671 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANDYOPADHYAY, SOURAV · 2014 to 2017
$1.8MNCI NIH HHS R01 CA098372NCI NIH HHS T32 CA108462NIDCR NIH HHS R01 DE023685NIDCR NIH HHS R01 DE028343NIGMS NIH HHS R01 GM107671
Abstract
PubMed holds no abstract for this paper.
Indexed as
Molecular Targeted TherapyAnimalsCarcinoma, Squamous CellCell Line, TumorElafinGene Expression Regulation, NeoplasticGene Expression Regulation, ViralHead and Neck NeoplasmsHuman papillomavirus 16HumansMiceOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsReceptor, ErbB-3Repressor ProteinsE6 protein, Human papillomavirus type 16ElafinERBB3 protein, humanOncogene Proteins, ViralPapillomavirus E7 ProteinsPI3 protein, humanReceptor, ErbB-3Repressor ProteinsRNA, Small Interfering
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.