Evidence map›Paper›PMID 27986699›Full record

ArticleArchives of disease in childhood2017

Ethnic and socioeconomic variation in incidence of congenital heart defects.

Rachel L Knowles, Deborah Ridout, Sonya Crowe, Catherine Bull, Jo Wray, Jenifer Tregay, Rodney C Franklin, David J Barron, David Cunningham, Roger C Parslow and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Archives of disease in childhood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 98 citations in OpenAlex.

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  6. Congenital heart diseases: population-based cross-sectional study and spatial analysis, São Paulo, 2012-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rachel L KnowlesPopulation Policy and Practice Programme, UCL Great Ormond St Institute of Child Health, University College London, London, UK.
Deborah RidoutPopulation Policy and Practice Programme, UCL Great Ormond St Institute of Child Health, University College London, London, UK.
Sonya CroweClinical Operational Research Unit, University College London, London, UK.
Catherine BullCardiac Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Jo WrayCardiac Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Jenifer TregayCardiac Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Rodney C FranklinPaediatric Cardiology Department, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
David J BarronBirmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
David CunninghamNational Institute for Cardiovascular Outcomes (NICOR), London, UK.
Roger C ParslowPaediatric Intensive Care Audit Network (PICANet), Leeds, UK.
Katherine L BrownCardiac Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College London · GBBirmingham Children's Hospital · GBIntensive Care Society · GBRoyal Brompton & Harefield NHS Foundation Trust · GB

Funding

Department of Health 10/2002/29
6 · The paper itself

Abstract

introductionEthnic differences in the birth prevalence of congenital heart defects (CHDs) have been reported; however, studies of the contemporary UK population are lacking. We investigated ethnic variations in incidence of serious CHDs requiring cardiac intervention before 1 year of age.

methodsAll infants who had a cardiac intervention in England and Wales between 1 January 2005 and 31 December 2010 were identified in the national congenital heart disease surgical audit and matched with paediatric intensive care admission records to create linked individual child records. Agreement in reporting of ethnic group by each audit was evaluated. For infants born 1 January 2006 to 31 December 2009, we calculated incidence rate ratios (IRRs) for CHDs by ethnicity and investigated age at intervention, antenatal diagnosis and area deprivation.

resultsWe identified 5350 infants (2940 (55.0%) boys). Overall CHD incidence was significantly higher in Asian and Black ethnic groups compared with the White reference population (incidence rate ratios (IRR) (95% CIs): Asian 1.5 (1.4 to 1.7); Black 1.4 (1.3 to 1.6)); incidence of specific CHDs varied by ethnicity. No significant differences in age at intervention or antenatal diagnosis rates were identified but affected children from non-White ethnic groups were more likely to be living in deprived areas than White children.

conclusionsSignificant ethnic variations exist in the incidence of CHDs, including for specific defects with high infant mortality. It is essential that healthcare provision mitigates ethnic disparity, including through timely identification of CHDs at screening, supporting parental choice and effective interventions. Future research should explore the factors underlying ethnic variation and impact on longer-term outcomes.

Indexed as

Asian PeopleBlack PeopleEnglandFemaleHeart Defects, CongenitalHumansIncidenceInfantInfant, NewbornIntensive Care Units, PediatricMaleMedical AuditPoverty AreasPrenatal DiagnosisSocioeconomic FactorsWalescongenital heart diseaseEpidemiologyethnicityrecord linkagesocio-economic deprivation

Identifiers

PMID27986699
PMCPMC5466927
OpenAlexW2566254825

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.