Evidence map›Paper›PMID 27986659›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Differential effects of Mas receptor deficiency on cardiac function and blood pressure in obese male and female mice.

Yu Wang, Robin Shoemaker, David Powell, Wen Su, Sean Thatcher, Lisa Cassis

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Review
  7. Article
  8. Sex differences in cardiovascular actions of the renin-angiotensin system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018
    Article
  17. Review
  18. Metformin attenuates ER stress-induced mitochondrial dysfunction.Translational research : the journal of laboratory and clinical medicine · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu WangDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Robin ShoemakerDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
David PowellDepartment of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky; and.
Wen SuDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
Sean ThatcherDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Lisa CassisDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky; lcassis@uky.edu.
University of Kentucky · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
Angiotensin: A Link Between Obesity and HypertensionR01HL073085 · NHLBI · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2003 to 2017
$5.0M
NHLBI NIH HHS R01 HL073085NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

Angiotensin-(1-7) [ANG-(1-7)] acts at Mas receptors (MasR) to oppose effects of angiotensin II (ANG II). Previous studies demonstrated that protection of female mice from obesity-induced hypertension was associated with increased systemic ANG-(1-7), whereas male obese hypertensive mice exhibited increased systemic ANG II. We hypothesized that MasR deficiency (

Indexed as

Angiotensin IAnimalsBlood PressureDiet, High-FatEchocardiographyFemaleHeartHeart Function TestsHypertensionHypertrophy, Left VentricularImmunohistochemistryMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, KnockoutAngiotensin Iangiotensin I (1-7)Peptide FragmentsProto-Oncogene MasProto-Oncogene ProteinsReceptors, G-Protein-Coupledangiotensin-(1–7)hypertensionobesity

Identifiers

PMID27986659
PMCPMC5402015
OpenAlexW2565128245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.