ArticleOsteoarthritis and cartilage2017
Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Comorbid hypertension and osteoarthritis exacerbates joint remodeling and gait compensations in female rats with milder effects observed in males.Osteoarthritis and cartilage open · 2025Article
- Gait assessment in a female rat Sprague Dawley model of disc-associated low back pain.Connective tissue research · 2024Article
- Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- A synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2024Review
- Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats.Research square · 2023Article
- Recommendations for the analysis of rodent gait data to evaluate osteoarthritis treatments.Osteoarthritis and cartilage · 2023Review
- Age alters gait compensations following meniscal injury in male rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait.PLoS computational biology · 2022Article
- Article
- Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats.Heliyon · 2021Article
- Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-κB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis.Probiotics and antimicrobial proteins · 2021Article
- Early-stage knee OA induced by MIA and MMT compared in the murine model via histological and topographical approaches.Scientific reports · 2020Article
- Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models.Laboratory animals · 2020Review
- Article
- The effects of age on the severity of joint damage and intra-articular inflammation following a simulated medial meniscus injury in 3, 6, and 9 month old male rats.Connective tissue research · 2020Article
- Functional Measures of Grip Strength and Gait Remain Altered Long-term in a Rat Model of Post-traumatic Elbow Contracture.Journal of biomechanical engineering · 2019Article
- Osteoarthritis year in review 2018: mechanics.Osteoarthritis and cartilage · 2019Review
- The Open Source GAITOR Suite for Rodent Gait Analysis.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn rodent osteoarthritis (OA) models, behavioral changes are often subtle and require highly sensitive methods to detect these changes. Gait analysis is one assay that may provide sensitive, quantitative measurement of these behavioral changes. To increase detection sensitivity of gait assessments relative to spatiotemporal gait collection alone, we combined our spatiotemporal and dynamic gait collection systems. Using this combined system, gait was assessed in the rat medial meniscus transection (MMT) model and monoiodoacetate (MIA) injection model of knee OA.
design36 male Lewis rats were separated into MMT (n = 8), medial collateral ligament transection (MCLT) (n = 8), skin incision (n = 4), MIA injection (n = 8), and saline injection (n = 8) groups. After initiation of OA, gait data were collected weekly in each group out to 4 weeks.
resultsThe MMT and MIA injection models produced unique pathologic gait profiles, with MMT animals developing a shuffling gait and MIA injection animals exhibiting antalgic gait. Spatiotemporal changes were also observed in the MMT model at week 1 (P < 0.01), but were not observed in the MIA injection model until week 3 (P < 0.01). Dynamic gait changes were observed in both models as early as 1 week post-surgery (P < 0.01).
conclusionCombined analysis of spatiotemporal and dynamic gait data increased detection sensitivity for gait modification in two rat OA models. Analyzing the combined gait data provided a robust characterization of the pathologic gait produced by each model. Furthermore, this characterization revealed different patterns of gait compensations in two common rat models of knee OA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.