Evidence map›Paper›PMID 27986568›Full record

ArticleBiochemical and biophysical research communications2017

Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.

Vladimir L Kolossov, Nagendraprabhu Ponnuraj, Jessica N Beaudoin, Matthew T Leslie, Paul J Kenis, H Rex Gaskins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vladimir L KolossovCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address: viadimer@illinois.edu.
Nagendraprabhu PonnurajCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
Jessica N BeaudoinCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
Matthew T LeslieCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
Paul J KenisCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
H Rex GaskinsCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
University of Illinois Urbana-Champaign · US

Funding

FRET-based Biosensors to Monitor Redox in Cell Cycle RegulationR33CA137719 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GASKINS, REX, KENIS, PAUL J. A. · 2010 to 2012
$842k
NCI NIH HHS R33 CA137719
6 · The paper itself

Abstract

Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production. A genetically encoded redox-sensitive probe was used to monitor intraorganellar glutathione redox potentials (E

Indexed as

Antineoplastic AgentsBiosensing TechniquesCell Line, TumorCytosolDicumarolFluorescent DyesGlutaredoxinsGlutathioneGreen Fluorescent ProteinsHumansIndolequinonesMitochondriaMolecular ImagingMolecular ProbesMolecular Targeted TherapyNAD(P)H Dehydrogenase (Quinone)5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dioneAntineoplastic Agentsbeta-lapachonedeoxynyboquinoneDicumarolFluorescent DyesGlutaredoxinsGlutathioneGreen Fluorescent ProteinsIndolequinonesMolecular ProbesNAD(P)H Dehydrogenase (Quinone)NaphthoquinonesNQO1 protein, humanQuinonesReactive Oxygen SpeciesDNQ and β-lapachoneLung and pancreatic cancerNQO1Redox homeostasisroGFP2 redox probe

Identifiers

PMID27986568
PMCPMC5253246
OpenAlexW2567526587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.