Evidence map›Paper›PMID 27986501›Full record

ArticleJournal of geriatric oncology2017

Motivation and mortality in older women with early stage breast cancer: A longitudinal study with ten years of follow-up.

Clark Dumontier, Kerri M Clough-Gorr, Rebecca A Silliman, Andreas E Stuck, André Moser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clark DumontierInternal Medicine Residency Program, Boston Medical Center, 72 East Concord Street, Evans 124, Boston, MA 02118, USA.
Kerri M Clough-GorrInstitute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland.
Rebecca A SillimanSection of Geriatrics, Boston Medical Center/Boston University School of Medicine, 88 East Newton Street, Robinson Building, Boston, MA 02118, USA. Electronic address: rsillima@bu.edu.
Andreas E StuckDepartment of Geriatrics, Inselspital, Bern University Hospital, and University of Bern, Switzerland.
André MoserInstitute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland; Department of Geriatrics, Inselspital, Bern University Hospital, and University of Bern, Switzerland.

Funding

BREAST CANCER TREATMENT OUTCOMES IN OLDER WOMENR01CA084506 · NCI · BOSTON MEDICAL CENTER · PI SILLIMAN, REBECCA A · 2000 to 2003
$2.7M
Impact of Breast Cancer on Older SurvivorsR01CA106979 · NCI · BOSTON MEDICAL CENTER · PI SILLIMAN, REBECCA A · 2004 to 2008
$1.5M
NCI NIH HHS R01 CA084506NCI NIH HHS R01 CA106979
6 · The paper itself

Abstract

objectivesThe Getting Out of Bed Scale (GOB) was validated as a health-related quality of life (HRQoL) variable in older women with early stage breast cancer, suggesting its potential as a concise yet powerful measure of motivation. The aim of our project was to assess the association between GOB and mortality over 10years of follow-up. MATERIALS AND

methodsWe studied 660 women ≥65-years old diagnosed with stage I-IIIA primary breast cancer. Data were collected over 10years of follow-up from interviews, medical records, and death indexes.

resultsCompared to women with lower GOB scores, women with higher GOB had an unadjusted hazard ratio (HR) of all-cause mortality of 0.78 at 5years, 95% confidence interval (CI) (0.52, 1.19) and 0.77 at 10years, 95%CI (0.59, 1.00). These associations diminished after adjusting for age and stage of breast cancer, and further after adjusting for other HRQoL variables including physical function, mental health, emotional health, psychosocial function, and social support. Unadjusted HRs of breast cancer-specific mortality were 0.92, 95%CI (0.49, 1.74), at 5years, and 0.82, 95%CI (0.52, 1.32), at 10years. These associations also decreased in adjusted models.

conclusionWomen with higher GOB scores had a lower hazard of all-cause mortality in unadjusted analysis. This effect diminished after adjusting for confounding clinical and HRQoL variables. GOB is a measure of motivation that may not be independently associated with cancer mortality, but reflects other HRQoL variables making it a potential outcome to monitor in older patients with cancer.

Indexed as

MotivationQuality of LifeActivities of Daily LivingAgedAged, 80 and overAge FactorsBreast NeoplasmsFemaleHumansLongitudinal StudiesNeoplasm StagingProportional Hazards ModelsBreast cancerDisease-specific mortalityGeriatric oncologyHealth-related quality of lifeMortalityMotivationQuality of lifeRisk stratificationSurvivorship

Identifiers

PMID27986501
PMCPMC5373974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.