ArticleImmunity2016
CD8
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 96 citations in OpenAlex.
- H3.3 chaperone Hira primes the effector program and function of regulatory T cells.Science advances · 2026Article
- The mechano-immunological landscape in the tumor microenvironment: From mechanical sensing to a new therapeutic paradigm.Materials today. Bio · 2026Review
- MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.bioRxiv : the preprint server for biology · 2026Article
- TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8Nature communications · 2025Article
- Autoimmune CD4Immunity · 2024Article
- Enhancers in T Cell development and malignant lesions.Cell death discovery · 2024Review
- Epigenome editing technologies for discovery and medicine.Nature biotechnology · 2024Review
- Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction.Immunity · 2024Article
- scButterfly: a versatile single-cell cross-modality translation method via dual-aligned variational autoencoders.Nature communications · 2024Article
- ECSIT facilitates memory CD8Nature cell biology · 2024Article
- Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.Immunity · 2024Article
- Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.Immunity · 2024Article
- Dysregulation of epigenetic modifications in inborn errors of immunity.Epigenomics · 2024Review
- Antigen exposure reshapes chromatin architecture in central memory CD8Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8Immunity · 2023Article
- Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Three-dimensional genome organization in immune cell fate and function.Nature reviews. Immunology · 2023Review
- Maintenance and recall of memory T cell populations against tuberculosis: Implications for vaccine design.Frontiers in immunology · 2023Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Bing HeDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shaojun XingDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Changya ChenInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.
Peng GaoDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Li TengIllumina Inc., San Diego, CA 92122, USA.
Qiang ShanDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jodi A GullicksrudDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA.
Matthew D MartinDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA.
Shuyang YuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China 100193.
John T HartyDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA.
Vladimir P BadovinacDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA.
Kai TanDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: tank1@email.chop.edu.
Hai-Hui XueDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: hai-hui-xue@uiowa.edu.
University of Iowa · USChildren's Hospital of Philadelphia · USChina Agricultural University · CNIllumina (United States) · USUniversity of Pennsylvania · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MTcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MRegulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MMemory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4MT resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4MEPIGENETIC REGULATION OF STEM CELL FATE CHOICER01HG006130 · NHGRI · UNIVERSITY OF IOWA · PI TAN, KAI · 2012 to 2016
$1.7MComputational Methods for Unraveling Combinatorial Gene RegulationR01GM108716 · NIGMS · UNIVERSITY OF IOWA · PI TAN, KAI · 2014 to 2017
$1.2MA TOOLKIT FOR IDENTIFYING CAUSAL VARIANTS IN TRANSCRIPTIONAL ENHANCERSR01GM104369 · NIGMS · UNIVERSITY OF IOWA · PI TAN, KAI · 2014 to 2017
$1.2MImpairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2MEpigenomic landscape in naive, effector, and memory CD8 T cellsR21AI115149 · NIAID · UNIVERSITY OF IOWA · PI TAN, KAI, XUE, HAI-HUI · 2015 to 2016
$417kMolecular mechanisms controlling differentiation of memory CD8 T cellsR21AI119160 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, XUE, HAI-HUI · 2015 to 2016
$414kBLRD VA I01 BX002903NHGRI NIH HHS R01 HG006130NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R21 AI042767NIAID NIH HHS R21 AI105351NIAID NIH HHS R21 AI115149NIAID NIH HHS R21 AI119160NIAID NIH HHS R37 AI042767NIGMS NIH HHS R01 GM104369NIGMS NIH HHS R01 GM108716NIGMS NIH HHS R01 GM113961
Abstract
Differentiation of effector and memory CD8
Indexed as
AlgorithmsAnimalsArenaviridae InfectionsCD8-Positive T-LymphocytesCell DifferentiationChromatin ImmunoprecipitationComputational BiologyDisease Models, AnimalEnhancer Elements, GeneticEpigenomicsGene Expression RegulationGene Regulatory NetworksHigh-Throughput Nucleotide SequencingLymphocyte ActivationLymphocytic choriomeningitis virusMiceCD8 T cellsCentral memoryEffector CD8 T cellsEnhancer-promoter interactomeEnhancersEpigeneticsHi-CNaïve CD8 T cellsSuper enhancersTranscriptional regulatory network
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.