ArticleExperimental and molecular pathology2017
World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung.
Article in Experimental and molecular pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Coal mining environment causes adverse effects on workers.Frontiers in public health · 2024Article
- D-ROMs and PAT Tests Reveal a High Level of Oxidative Stress in Patients with Severe Well-Controlled Asthma, and D-ROMs Are Positively Correlated with R20 Values That Indicate Approximate Central Airway Resistance.Journal of personalized medicine · 2023Article
- Analysis of influencing factors and a predictive model of small airway dysfunction in adults.BMC pulmonary medicine · 2023Article
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- Cancer risk among World Trade Center rescue and recovery workers: A review.CA: a cancer journal for clinicians · 2022Review
- Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases.Carcinogenesis · 2022Article
- The role of environmental exposures and gene-environment interactions in the etiology of systemic lupus erythematous.Journal of internal medicine · 2022Review
- Global DNA Methylation Profiles in Peripheral Blood of WTC-Exposed Community Members with Breast Cancer.International journal of environmental research and public health · 2022Article
- Neuroinflammation in World Trade Center responders at midlife: A pilot study using [Brain, behavior, & immunity - health · 2021Article
- Oscillometry of the respiratory system: a translational opportunity not to be missed.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Lung Cancer Characteristics in the World Trade Center Environmental Health Center.International journal of environmental research and public health · 2021Article
- Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes.International journal of environmental research and public health · 2020Article
- Excess HPV-related head and neck cancer in the world trade center health program general responder cohort.International journal of cancer · 2019Article
- Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade.Molecular cancer research : MCR · 2019Article
- Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers.International journal of environmental research and public health · 2019Article
- Understanding the role of environmental factors in the development of systemic lupus erythematosus.Best practice & research. Clinical rheumatology · 2017Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to World Trade Center (WTC) dust has been linked to respiratory disease in humans. In the present studies we developed a rodent model of WTC dust exposure to analyze lung oxidative stress and inflammation, with the goal of elucidating potential epigenetic mechanisms underlying these responses. Exposure of mice to WTC dust (20μg, i.t.) was associated with upregulation of heme oxygenase-1 and cyclooxygenase-2 within 3days, a response which persisted for at least 21days. Whereas matrix metalloproteinase was upregulated 7days post-WTC dust exposure, IL-6RA1 was increased at 21days; conversely, expression of mannose receptor, a scavenger receptor important in particle clearance, decreased. After WTC dust exposure, increases in methylation of histone H3 lysine K4 at 3days, lysine K27 at 7days and lysine K36, were observed in the lung, along with hypermethylation of Line-1 element at 21days. Alterations in pulmonary mechanics were also observed following WTC dust exposure. Thus, 3days post-exposure, lung resistance and tissue damping were decreased. In contrast at 21days, lung resistance, central airway resistance, tissue damping and tissue elastance were increased. These data demonstrate that WTC dust-induced inflammation and oxidative stress are associated with epigenetic modifications in the lung and altered pulmonary mechanics. These changes may contribute to the development of WTC dust pathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.