Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Exercise interventions preserve hippocampal volume: A meta-analysis.Hippocampus · 2021Pooled it
- Text Message Interventions for Physical Activity: A Systematic Review and Meta-Analysis.American journal of preventive medicine · 2020Pooled it
- Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies.NeuroImage. Clinical · 2019Pooled it
- Trial
- Hippocampal subfield plasticity is associated with improved spatial memory.Communications biology · 2024Trial
- Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults.GeroScience · 2023Trial
- Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study.NeuroImage. Clinical · 2022Trial
- Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Few Structural Brain Changes Associated With Moderate-Intensity Interval Training and Low-Intensity Continuous Training in a Randomized Trial of Fitness and Older Adults.Journal of aging and physical activity · 2021Trial
- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- Effect of 5 Years of Exercise Intervention at Different Intensities on Brain Structure in Older Adults from the General Population: A Generation 100 Substudy.Clinical interventions in aging · 2021Trial
- Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults.Hippocampus · 2020Trial
- Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients.Translational psychiatry · 2019Trial
- Physical Activity and Cerebral Small Vein Integrity in Older Adults.Medicine and science in sports and exercise · 2019Trial
- Neural correlates of perceived physical and mental fatigability in older adults: A pilot study.Experimental gerontology · 2019Trial
- Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia.Translational psychiatry · 2017Trial
- Efficacy and mechanisms underlying MRI-guided HD-tDCS combined with aerobic exercise to ameliorate cognitive impairment associated with schizophrenia.Frontiers in psychiatry · 2026Article
- Physical activity changes during midlife link to brain integrity and amyloid burden.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Exercise Benefits Dentate Gyrus Function: Bridging from Animal Models to Human High-Resolution Functional MRI of Pattern Separation.Advances in neurobiology · 2025Review
- The relationship between leisure time physical activity patterns, Alzheimer's disease markers and cognition.Brain communications · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGreater hippocampal volume is observed in healthy older adults after short-term structured exercise. Whether long-term exposure to real-world physical activity (PA) programs has similar effects for sedentary older adults with impaired mobility and comorbid conditions is not known. HYPOTHESIS: A long-term moderate intensity regimen of PA is related to larger volume of the hippocampus in older adults at risk for mobility disability. We further explore whether these associations are modified by factors known to be related to dementia.
methodsTwenty-six sedentary adults at risk for mobility disability participated in a 24-month randomized intervention program of physical activity (PA, N = 10, age: 74.9 years, 7 women) or health education (HE, N = 16, age: 76.8 years, 14 women). Volumes of total hippocampus, dentate gyrus, and cornu ammonis were measured at baseline and at 24-month follow-up using 7-Tesla magnetic resonance imaging. Between-group volumetric differences at 24 months were adjusted for sessions attended and baseline volumes. The contribution of each dementia-related factor was tested separately for education, APOE, diabetes, cardiovascular diseases, white matter hyperintensities, and brain atrophy.
resultsBetween-group differences were significant for left hippocampus, left cornu ammonis, and right hippocampus. Adjustment for regional baseline volume attenuated the associations to statistically nonsignificant for right hippocampus and left conru ammonis; associations for left hippocampus were robust for all adjustments. Results were similar after adjustment for dementia-related factors.
conclusionsIn this group of sedentary older adults there was a hippocampal response to a long-term program of moderate-intensity PA. Future studies should examine whether hippocampal response could explain the beneficial effects of PA on cognition for vulnerable older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.