ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis.Neuropsychology review · 2020Pooled it
- Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial.JAMA network open · 2021Trial
- Hypergraph clustering for analyzing chronic disease patterns in mild cognitive impairment reversion and progression.Scientific reports · 2025Article
- Predictors of Transition from Mild Cognitive Impairment to Normal Cognition and Dementia.Behavioral sciences (Basel, Switzerland) · 2025Article
- The mediating effect of activities of daily living (ADL) disability on the association between depressive symptoms and cognitive impairment in older adults: a National study.BMC geriatrics · 2025Article
- Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The Impact of Chronic Pain on Cognitive Function.Brain sciences · 2025Review
- Characterization of subclinical depressive and anxiety symptoms in older adults with subjective cognitive decline progressing to objective cognitive impairment: A prospective 4-year follow-up study.Journal of Alzheimer's disease : JAD · 2025Article
- Systematic identification and quantification of factors and their interactions with age, sex, and panel wave influencing cognitive function in Korean older adults.Frontiers in public health · 2025Article
- Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease.International journal of aging & human development · 2025Article
- Cross-sectional and longitudinal associations between late-life depressive symptoms and cognitive deficits: 20-year follow-up of the Kuakini Honolulu-Asia aging study.Archives of gerontology and geriatrics · 2024Article
- The WMI Rat of Premature Cognitive Aging Presents Intrinsic Vulnerability to Oxidative Stress in Primary Neurons and Astrocytes Compared to Its Nearly Isogenic WLI Control.International journal of molecular sciences · 2024Article
- Risk Factors for Falls and Fall-Related Fractures in Community-Living Older People with Pain: A Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review.JAR life · 2023Article
- Sex, Neuropsychiatric Profiles, and Caregiver Burden in Alzheimer's Disease Dementia: A Latent Class Analysis.Journal of Alzheimer's disease : JAD · 2022Article
- Sociodemographic, Lifestyle, Physical, and Psychosocial Determinants of Cognitive Reserve.Journal of Alzheimer's disease : JAD · 2022Article
- Association of Depressive Symptoms and Cognition in Older Adults Without Dementia Across Different Biomarker Profiles.Journal of Alzheimer's disease : JAD · 2022Article
- Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer's Disease with Depression.Journal of Alzheimer's disease : JAD · 2022Article
- Depressive Symptoms and Cognitive Decline Among Chinese Rural Elderly Individuals: A Longitudinal Study With 2-Year Follow-Up.Frontiers in public health · 2022Article
Corrections and comments
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3 authors.
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Abstract
objectiveThe relationship between depressive symptoms and subsequent cognitive impairment in older adults is controversial. Sex differences and the differences in the method of categorizing depressive symptoms may contribute to the inconsistencies. The authors examined the effect of severity of baseline depressive symptoms on risk of incident amnestic mild cognitive impairment (aMCI) separately in men and women.
methodsCommunity-dwelling and cognitively healthy older adults (aged ≥ 70 years) from the Einstein Aging Study completed the 15-item Geriatric Depression Scale (GDS-15) at their baseline visit. Participants were categorized into "no/low symptoms" (GDS-15 score = 0-2), "mild symptoms" (GDS-15 score = 3-5), and "moderate/severe symptoms" (GDS-15 score > 6) groups. Sex-stratified Cox proportional hazards models, adjusted for age, education, and antidepressant medication, estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident aMCI as a function of depressive symptoms group.
resultsWe followed 572 women (mean age: 78) and 345 men (mean age: 77) for 4.2 years on average (range: 1.0-14.6 years). Ninety women and 64 men developed aMCI during follow-up. Cox models revealed that compared with no/low depressive symptoms, mild symptoms were associated with a two times greater risk of developing aMCI in men (HR: 2.22; 95% CI: 1.26-3.89) but not in women (HR: 1.26; 95% CI: 0.77-2.06). Conversely, moderate/severe depressive symptoms were associated with a two times greater risk of developing aMCI in women (HR: 1.99; 95% CI: 1.05-3.77) but not in men (HR: 0.28; 95% CI: 0.04-2.11), possibly because of low statistical power in this subgroup.
conclusionResults indicate that mild depressive symptoms in men and moderate/severe symptoms in women may represent a marker for future cognitive impairment.
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