Evidence map›Paper›PMID 27986209›Full record

ReviewSeminars in radiation oncology2017

Prostate Cancer Genetics: Variation by Race, Ethnicity, and Geography.

Timothy R Rebbeck

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in radiation oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Empirically derived dietary patterns and prostate cancer risk: a systematic review and meta-analysis of prospective cohorts.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
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  15. High-Resolution Melting PCR-Based SNP Germline Genotyping ofDiagnostics (Basel, Switzerland) · 2026
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122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Timothy R RebbeckDepartment of Medical Oncology Dana Farber Cancer Institute, Boston, MA; Department of Epidemiology Harvard TH Chan School of Public Health, Boston, MA. Electronic address: Timothy_Rebbeck@dfci.harvard.edu.

Funding

Segregation and Racial Disparities in Prostate CancerP50CA105641 · NCI · UNIVERSITY OF PENNSYLVANIA · PI REBBECK, TIMOTHY R · 2003 to 2009
$9.6M
Research Traiing/Education CoreP60MD006900 · NIMHD · UNIVERSITY OF PENNSYLVANIA · PI GLANZ, KAREN · 2012 to 2016
$6.6M
NCI NIH HHS P50 CA105641NIMHD NIH HHS P60 MD006900
6 · The paper itself

Abstract

Prostate cancer rates vary substantially by race, ethnicity, and geography. These disparities can be explained by variation in access to screening and treatment, variation in exposure to prostate cancer risk factors, and variation in the underlying biology of prostate carcinogenesis (including genomic propensity of some groups to develop biologically aggressive disease). It is clear that access to screening and access to treatment are critical influencing factors of prostate cancer rates; yet, even among geographically diverse populations with similar access to care (eg, low- and medium-income countries), African descent men have higher prostate cancer rates and poorer prognosis. To date, the proportion of prostate cancer that can be explained by environmental exposures is small, and the effect of these factors across different racial, ethnic, or geographical populations is poorly understood. In contrast, prostate cancer has one of the highest heritabilities of all major cancers. Numerous genetic susceptibility markers have been identified from family-based studies, candidate gene association studies, and genome-wide association studies. Some prostate cancer loci, including the risk loci found at chromosome 8q24, have consistent effects in all groups studied to date. However, replication of many susceptibility loci across race, ethnicity, and geography remains limited, and additional studies in certain populations (particularly in men of African descent) are needed to better understand the underlying genetic basis of prostate cancer.

Indexed as

Black PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyGeography, MedicalHealth Services AccessibilityHumansMalePrognosisProstatic Neoplasms

Identifiers

PMID27986209
PMCPMC5175208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.