ReviewJournal of orthopaedic surgery and research2016
Mesenchymal stem cells as therapeutic target of biophysical stimulation for the treatment of musculoskeletal disorders.
Review in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pain and Functional Scores in Patients Affected by Knee OA after Treatment with Pulsed Electromagnetic and Magnetic Fields: A Meta-Analysis.Cartilage · 2021Pooled it
- Review
- Pelvic apophysitis and avulsion fracture treated with a regenerative combination of extracorporeal shockwave therapy and extracorporeal magnetotransduction therapy in an adolescent soccer player.Wiener medizinische Wochenschrift (1946) · 2026Article
- Extracorporeal Shock Wave Therapy Promotes Peripheral Nerve Regeneration Through ERK1/2-Mediated Autophagy.Annals of the New York Academy of Sciences · 2026Article
- Extremely low frequency-electromagnetic fields promote chondrogenic differentiation of adipose-derived mesenchymal stem cells through a conventional genetic program.Scientific reports · 2024Article
- Pulsed Electromagnetic Fields (PEMF)-Physiological Response and Its Potential in Trauma Treatment.International journal of molecular sciences · 2023Review
- Cell therapy efficacy and safety in treating tendon disorders: a systemic review of clinical studies.Journal of experimental orthopaedics · 2022Review
- The effects of orthobiologics in the treatment of tendon pathologies: a systematic review of preclinical evidence.Journal of experimental orthopaedics · 2022Review
- Pulsed Electromagnetic Field Alleviates Intervertebral Disc Degeneration by Activating Sirt1-Autophagy Signaling Network.Frontiers in bioengineering and biotechnology · 2022Article
- Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future.Cells · 2021Review
- Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry.The Japanese dental science review · 2021Review
- Complementary and Alternative Modalities (CAM) for pain management in musculoskeletal diseases (MSDs).Journal of clinical orthopaedics and trauma · 2021Article
- Review
- Pulsed electromagnetic fields improve the healing process of Achilles tendinopathy: a pilot study in a rat model.Bone & joint research · 2020Article
- The greater inflammatory pathway-high clinical potential by innovative predictive, preventive, and personalized medical approach.The EPMA journal · 2020Review
- Coupling between Osseointegration and Mechanotransduction to Maintain Foreign Body Equilibrium in the Long-Term: A Comprehensive Overview.Journal of clinical medicine · 2019Review
- Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis.Frontiers in immunology · 2019Review
- Concise Review on Clinical Applications of Conditioned Medium Derived from Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs).International journal of hematology-oncology and stem cell research · 2018Review
- Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?Stem cell reviews and reports · 2018Review
- Effect of High-Induction Magnetic Stimulation on Elasticity of the Patellar Tendon.Journal of healthcare engineering · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMusculoskeletal disorders are regarded as a major cause of worldwide morbidity and disability, and they result in huge costs for national health care systems. Traditional therapies frequently turned out to be poorly effective in treating bone, cartilage, and tendon disorders or joint degeneration. As a consequence, the development of novel biological therapies that can treat more effectively these conditions should be the highest priority in regenerative medicine. Mesenchymal stem cells (MSCs) represent one of the most promising tools in musculoskeletal tissue regenerative medicine, thanks to their proliferation and differentiation potential and their immunomodulatory and trophic ability. Indeed, MSC-based approaches have been proposed for the treatment of almost all orthopedic conditions, starting from different cell sources, alone or in combination with scaffolds and growth factors, and in one-step or two-step procedures. While all these approaches would require cell harvesting and transplantation, the possibility to stimulate the endogenous MSCs to enhance their tissue homeostasis activity represents a less-invasive and cost-effective therapeutic strategy. Nowadays, the role of tissue-specific resident stem cells as possible therapeutic target in degenerative pathologies is underinvestigated. Biophysical stimulations, and in particular extracorporeal shock waves treatment and pulsed electromagnetic fields, are able to induce proliferation and support differentiation of MSCs from different origins and affect their paracrine production of growth factors and cytokines. SHORT
conclusionsThe present review reports the attempts to exploit the resident stem cell potential in musculoskeletal pathologies, highlighting the role of MSCs as therapeutic target of currently applied biophysical treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.