Evidence map›Paper›PMID 27984852›Full record

ArticleBiochemistry2017

Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPL

Cassandra K Hayne, Michael J Lafferty, Brian J Eglinger, John P Kane, Saskia B Neher

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  13. The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cassandra K HayneDepartment Biochemistry and Biophysics, University of North Carolina at Chapel Hill , 120 Mason Farm Road, CB7260, Chapel Hill, North Carolina 27599, United States.
Michael J LaffertyDepartment Biochemistry and Biophysics, University of North Carolina at Chapel Hill , 120 Mason Farm Road, CB7260, Chapel Hill, North Carolina 27599, United States.
Brian J EglingerDepartment Biochemistry and Biophysics, University of North Carolina at Chapel Hill , 120 Mason Farm Road, CB7260, Chapel Hill, North Carolina 27599, United States.
John P KaneUniversity of California San Francisco Medical Center , San Francisco, California 94115, United States.
Saskia B NeherDepartment Biochemistry and Biophysics, University of North Carolina at Chapel Hill , 120 Mason Farm Road, CB7260, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-4165-6674
University of North Carolina at Chapel Hill · USUniversity of California San Francisco Medical Center · US

Funding

Investigation of the Molecular Mechanisms of Lipoprotein Lipase InhibitorsR01HL125654 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NEHER, SASKIA · 2015 to 2024
$3.8M
NHLBI NIH HHS R01 HL125654
6 · The paper itself

Abstract

Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPL

Indexed as

MutationAngiopoietin-Like Protein 4AngiopoietinsAnimalsBiological TransportCholesterol, HDLCholesterol, LDLCholesterol, VLDLGene ExpressionHumansHyperlipidemiasLipoprotein LipaseMiceModels, MolecularProtein BindingProtein DomainsAngiopoietin-Like Protein 4AngiopoietinsANGPTL4 protein, humanCholesterol, HDLCholesterol, LDLCholesterol, VLDLGPIHBP1 protein, humanGPI-HBP1 protein, mouseLipoprotein LipaseLPL protein, humanReceptors, LipoproteinRecombinant ProteinsSerineTriglycerides

Identifiers

PMID27984852
PMCPMC5848218
OpenAlexW2565906942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.