Evidence map›Paper›PMID 27984783›Full record

ReviewCurrent opinion in microbiology2017

Autophagic targeting and avoidance in intracellular bacterial infections.

Lara J Kohler, Craig R Roy

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in microbiology · 2020
    Review
  11. Review
  12. Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface.Cellular and molecular gastroenterology and hepatology · 2017
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lara J KohlerDepartment of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
Craig R RoyDepartment of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA. Electronic address: craig.roy@yale.edu.

Funding

Genetic Analysis of Legionella Phagosome TraffickingR37AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2012 to 2021
$5.3M
Genetic Analysis of Legionella Phagosome TraffickingR01AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2002 to 2011
$4.1M
Biogenesis of the Coxiella-containing vacuoleR01AI114760 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2015 to 2019
$2.1M
Modulation of Host Cell Functions by Coxiella burnetiiR01AI064559 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2006 to 2010
$1.8M
GENETIC ANALYSIS OF LEGIONELLA PHAGOSOME TRAFFICKINGR29AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 1997 to 2001
$277k
NIAID NIH HHS R01 AI041699NIAID NIH HHS R01 AI064559NIAID NIH HHS R01 AI114760NIAID NIH HHS R29 AI041699NIAID NIH HHS R37 AI041699
6 · The paper itself

Abstract

Eukaryotic cells use autophagy to break down and recycle components such as aggregated proteins and damaged organelles. Research in the past decade, particularly using Salmonella enterica serovar Typhimurium as a model pathogen, has revealed that autophagy can also target invading intracellular bacterial pathogens for degradation. However, many bacterial pathogens have evolved mechanisms that allow for evasion of the autophagic pathway, such as motility or direct and irreversible cleavage of proteins that comprise the autophagic machinery. As a complete and detailed understanding of the autophagic pathway and its derivatives continues to develop, it is likely that other mechanisms of inhibition by bacterial pathogens will be discovered.

Indexed as

AutophagyAnimalsBacteriaBacterial InfectionsCytoplasmHumansImmunity, InnateSalmonella typhimurium

Identifiers

PMID27984783
PMCPMC5963723

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.