ArticleCell2016
Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2021 · on this mapPooled it
- Molecular mechanisms of metformin action: From metabolic effects to lifespan extension and healthspan promotion.Journal of medical biochemistry · 2026Article
- Enhancement of the Antioxidant Activity ofMolecules (Basel, Switzerland) · 2025Article
- Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body.Aging and disease · 2025Review
- Smartphone-Assisted Thin-Layer Chromatography for Rapid Quality Screening of Metformin.Advances in pharmacological and pharmaceutical sciences · 2025Article
- Metformin facilitates anti-PD-L1 efficacy through the regulation of intestinal microbiota.Genes and immunity · 2024Article
- Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2.Stem cell reviews and reports · 2023Article
- Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Antiaging agents: safe interventions to slow aging and healthy life span extension.Natural products and bioprospecting · 2022Review
- Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.BMC cancer · 2021Article
- Article
- Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.International journal of endocrinology · 2021Article
- A Bibliometrics Analysis of Metformin Development From 1980 to 2019.Frontiers in pharmacology · 2021Review
- BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions inInternational journal of molecular sciences · 2020Article
- Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression.Journal of experimental & clinical cancer research : CR · 2020Article
- Transcriptomic landscape profiling of metformin-treated healthy mice: Implication for potential hypertension risk when prophylactically used.Journal of cellular and molecular medicine · 2020Article
- Immunohistochemistry biomarker TP53 expression predicts the survival of thymomas.Gland surgery · 2020Article
- Metformin shows anti-inflammatory effects in murine macrophages through Dicer/microribonucleic acid-34a-5p and microribonucleic acid-125b-5p.Journal of diabetes investigation · 2020Article
- Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function.Frontiers in pharmacology · 2020Review
- lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.Cancer management and research · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this issue of Cell, Wu et al. employed C. elegans and human cell experiments to identify a pathway through which metformin increases lifespan and inhibits growth. A key transcriptional target, ACAD10, is activated when metformin induces nuclear exclusion of the GTPase RagC, thereby inhibiting mTORC1 through an unexpected mechanism.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.