Evidence map›Paper›PMID 27984652›Full record

ArticleCancer2017

A multi-institutional analysis of peritransplantation radiotherapy in patients with relapsed/refractory Hodgkin lymphoma undergoing autologous stem cell transplantation.

Sarah A Milgrom, Shekeab Jauhari, John P Plastaras, Yago Nieto, Bouthaina S Dabaja, Chelsea C Pinnix, Grace L Smith, Pamela K Allen, J Nicholas Lukens, Amit Maity and 3 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sarah A MilgromDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Shekeab JauhariDepartment of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
John P PlastarasDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Yago NietoDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Bouthaina S DabajaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chelsea C PinnixDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Grace L SmithDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Pamela K AllenDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J Nicholas LukensDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Amit MaityDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Yasuhiro OkiDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Michelle A FanaleDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sunita D NastaDepartment of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
The University of Texas MD Anderson Cancer Center · USUniversity of Pennsylvania · US

Funding

TRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6M
Economic Strain and Resilience in Cancer Patients: Assessing Patient-Reported Measures of the Burdens of TreatmentK07CA211804 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SMITH, GRACE · 2016 to 2020
$853k
NCI NIH HHS K07 CA211804NHLBI NIH HHS T32 HL007057
6 · The paper itself

Abstract

backgroundNo consensus exists regarding the use of radiotherapy (RT) in conjunction with high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) for patients with relapsed/refractory classical Hodgkin lymphoma (HL). The objectives of the current study were to characterize practice patterns and assess the efficacy and toxicity of RT at 2 major transplantation centers.

methodsEligible patients underwent HDC/ASCT from 2006 through 2015 using the combination of either carmustine (BCNU), etoposide, cytarabine, and melphalan (BEAM) or cyclophosphamide, BCNU, and etoposide (CBV).

resultsFor the cohort of 189 patients, the 4-year overall survival rate was 80%, the progression-free survival rate was 67%, and the local control (LC) rate was 68%. RT was used within 4 months of ASCT for 22 patients (12%) and was given more often for disease that was early stage, primary refractory, or [

conclusionsIn patients undergoing ASCT for relapsed/refractory HL, peritransplantation RT was used more often for disease that was early stage, primary refractory, or FDG-avid after salvage conventional-dose chemotherapy. RT was associated with improved LC of high-risk localized disease and was well tolerated with modern techniques. Cancer 2017;123:1363-1371. © 2016 American Cancer Society.

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyDrug Resistance, NeoplasmFemaleHodgkin DiseaseHumansMaleMiddle AgedNeoplasm StagingPositron-Emission TomographyRadiotherapy, AdjuvantRecurrenceTransplantation, AutologousHodgkin lymphomalymphomaradiotherapy (RT)stem cell transplantation (SCT)

Identifiers

PMID27984652
PMCPMC5811230
OpenAlexW2563933574

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.