ArticlePLoS computational biology2016
The Multilayer Connectome of Caenorhabditis elegans.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 299 citations in OpenAlex.
- Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity.PLoS computational biology · 2026Article
- Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops.BMC biology · 2026Article
- An entropic measure of diverse specialization highlights multifunctional neurons in annotated connectomes.Network neuroscience (Cambridge, Mass.) · 2026Article
- The volatile anesthetic isoflurane causes global suppression of neuronal activity, disrupting hub neuron function inFrontiers in systems neuroscience · 2026Article
- Article
- The Controllability ofBiomimetics (Basel, Switzerland) · 2025Article
- The dopaminergic system ofRoyal Society open science · 2025Review
- Bridging the gap between the connectome and whole-brain activity inbioRxiv : the preprint server for biology · 2025Article
- The role of structural connectivity on brain function through a Markov model of signal transmission.bioRxiv : the preprint server for biology · 2025Article
- Article
- Dopaminergic Modulation of Short-Term Associative Memory in Caenorhabditis elegans.Journal of neurochemistry · 2025Article
- Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species.Current biology : CB · 2025Article
- Mapping and decoding neuropeptide signaling networks in nervous system function.Current opinion in neurobiology · 2025Review
- The role of structural connectivity on brain function through a Markov model of signal transmission.PloS one · 2025Article
- Review
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- Large-scale deorphanization ofeLife · 2024Article
- A tonically active master neuron modulates mutually exclusive motor states at two timescales.Science advances · 2024Article
- Heavy-tailed neuronal connectivity arises from Hebbian self-organization.Nature physics · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function and occurs primarily outside the synaptic connectome. We have mapped the putative monoamine connections, as well as a subset of neuropeptide connections, in C. elegans based on new and published gene expression data. The monoamine and neuropeptide networks exhibit distinct topological properties, with the monoamine network displaying a highly disassortative star-like structure with a rich-club of interconnected broadcasting hubs, and the neuropeptide network showing a more recurrent, highly clustered topology. Despite the low degree of overlap between the extrasynaptic (or wireless) and synaptic (or wired) connectomes, we find highly significant multilink motifs of interaction, pinpointing locations in the network where aminergic and neuropeptide signalling modulate synaptic activity. Thus, the C. elegans connectome can be mapped as a multiplex network with synaptic, gap junction, and neuromodulator layers representing alternative modes of interaction between neurons. This provides a new topological plan for understanding how aminergic and peptidergic modulation of behaviour is achieved by specific motifs and loci of integration between hard-wired synaptic or junctional circuits and extrasynaptic signals wirelessly broadcast from a small number of modulatory neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.