Evidence map›Paper›PMID 27984203›Full record

ReviewBiochimie2017

UCP1: A transporter for H

Ambre M Bertholet, Yuriy Kirichok

Open access · greenAbstract readReview
In one paragraph

Review in Biochimie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Frontiers in pharmacology · 2026
    Article
  8. Article
  9. Interactions of Arachidonic Acid with AAC1 and UCP1.International journal of molecular sciences · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Interconnected roles of mitochondrial carrier proteins ANT, PFrontiers in molecular biosciences · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ambre M BertholetDepartment of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, CA 94158, USA.
Yuriy KirichokDepartment of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, CA 94158, USA. Electronic address: yuriy.kirichok@ucsf.edu.
University of California, San Francisco · US

Funding

Mitochondrial Uncoupling and Thermogenesis in Adipose TissuesR01GM107710 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIRICHOK, YURIY · 2015 to 2018
$1.6M
NIGMS NIH HHS R01 GM107710
6 · The paper itself

Abstract

Adaptive thermogenesis regulates core body temperature, controls fat deposition, and contributes strongly to the overall energy balance. This process occurs in brown fat and requires uncoupling protein 1 (UCP1), an integral protein of the inner mitochondrial membrane. Classic biochemical studies revealed the general principle of adaptive thermogenesis: in the presence of long-chain fatty acids (FA), UCP1 increases the permeability of the inner mitochondrial membrane for H

Indexed as

ProtonsAdipocytes, BrownAdipose Tissue, BrownAnimalsEnergy MetabolismFatty AcidsGene Expression RegulationHumansIon TransportMitochondriaMitochondrial MembranesModels, MolecularPatch-Clamp TechniquesThermogenesisUncoupling Protein 1Fatty AcidsProtonsUncoupling Protein 1Brown fatFatty acidMitochondriaThermogenesisUCP1Uncoupling

Identifiers

PMID27984203
PMCPMC5461058
OpenAlexW2546278073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.