Evidence map›Paper›PMID 27983819›Full record

ArticleJournal of the American Chemical Society2017

A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water.

Roshan W Gunasekara, Yan Zhao

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Substrate Protection in Controlled Enzymatic Transformation of Peptides and Proteins.Chembiochem : a European journal of chemical biology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Unprotected Galactosamine as a Dynamic Key for a Cyclochiral Lock.Journal of the American Society for Mass Spectrometry · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Synthetic lectins for selective binding of glycoproteins in water.Chemical communications (Cambridge, England) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Roshan W GunasekaraDepartment of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
Yan ZhaoDepartment of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.ORCID 0000-0003-1215-2565
Iowa State University · US

Funding

Biomimetic Receptors for Small Hydrophobic Drugs, Carbohydrates, and OligopeptidesR01GM113883 · NIGMS · IOWA STATE UNIVERSITY · PI ZHAO, YAN · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM113883
6 · The paper itself

Abstract

Molecular recognition of carbohydrates plays vital roles in biology but has been difficult to achieve with synthetic receptors. Through covalent imprinting of carbohydrates in boroxole-functionalized cross-linked micelles, we prepared nanoparticle receptors for a wide variety of mono- and oligosaccharides. The boroxole functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol. The protein-sized nanoparticles showed excellent selectivity for d-aldohexoses in water with submillimolar binding affinities and completely distinguished the three biologically important hexoses (glucose, mannose, and galactose). Glycosides with nonpolar aglycon showed stronger binding due to enhanced hydrophobic interactions. Oligosaccharides were distinguished on the basis of their monosaccharide building blocks, glycosidic linkages, chain length, as well as additional functional groups that could interact with the nanoparticles.

Indexed as

HexosesMolecular ImprintingMolecular StructureMonosaccharidesNanoparticlesOligosaccharidesWaterHexosesMonosaccharidesOligosaccharidesWater

Identifiers

PMID27983819
PMCPMC5243169
OpenAlexW2565341288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.