ReviewMetabolites2016
Current and Future Perspectives on the Structural Identification of Small Molecules in Biological Systems.
Review in Metabolites, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Hepatoprotective Effects of Maillard Reaction Products FromFood science & nutrition · 2026Article
- LC-QTOF-MS Chemical Characterization, Cytotoxicity, and Antimicrobial Activity of Blue Geopropolis: An Emerging Type of Brazilian Propolis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Bitter Compounds in Medicinal Food Plants Based on Traditional Chinese Medicine: Analysis and Regulation Strategies from Chemical Structure to Perception Mechanisms.Molecules (Basel, Switzerland) · 2026Review
- Article
- Structure Elucidation and Toxicity Analyses of the Degradation Products of Aflatoxin BJournal of fungi (Basel, Switzerland) · 2026Article
- 1H NMR spectra as a characteristic of herbal preparations.Journal of food science and technology · 2025Article
- Metabolomic profiling of Akebia species: Comparative analysis of bioactive compounds in the pulp ofFood chemistry: X · 2025Article
- Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome.Journal of clinical medicine · 2025Review
- Article
- Chemical Composition of Commercial Cannabis.Journal of agricultural and food chemistry · 2024Article
- Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure.Molecular omics · 2024Review
- Microbiome metabolite quantification methods enabling insights into human health and disease.Methods (San Diego, Calif.) · 2024Review
- Tripogon loliiformis tolerates rapid desiccation after metabolic and transcriptional priming during initial drying.Scientific reports · 2023Article
- GC-MS, quantum mechanics calculation and the antifungal activity of river red gum essential oil when applied to four natural textiles.Scientific reports · 2023Article
- DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data.Journal of cheminformatics · 2023Article
- Review
- Advances in Ultra-High-Resolution Mass Spectrometry for Pharmaceutical Analysis.Molecules (Basel, Switzerland) · 2023Review
- Omics-based ecosurveillance for the assessment of ecosystem function, health, and resilience.Emerging topics in life sciences · 2022Review
- Metabolic Footprinting of Microbial Systems Based on Comprehensive In Silico Predictions of MS/MS Relevant Data.Metabolites · 2022Article
- Metabolomics of plant root exudates: From sample preparation to data analysis.Frontiers in plant science · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although significant advances have been made in recent years, the structural elucidation of small molecules continues to remain a challenging issue for metabolite profiling. Many metabolomic studies feature unknown compounds; sometimes even in the list of features identified as "statistically significant" in the study. Such metabolic "dark matter" means that much of the potential information collected by metabolomics studies is lost. Accurate structure elucidation allows researchers to identify these compounds. This in turn, facilitates downstream metabolite pathway analysis, and a better understanding of the underlying biology of the system under investigation. This review covers a range of methods for the structural elucidation of individual compounds, including those based on gas and liquid chromatography hyphenated to mass spectrometry, single and multi-dimensional nuclear magnetic resonance spectroscopy, and high-resolution mass spectrometry and includes discussion of data standardization. Future perspectives in structure elucidation are also discussed; with a focus on the potential development of instruments and techniques, in both nuclear magnetic resonance spectroscopy and mass spectrometry that, may help solve some of the current issues that are hampering the complete identification of metabolite structure and function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.