ArticleNature communications2016
Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Therapeutic Poxviruses Induce the Secretion of Immunostimulating and Anti-Tumoral Extracellular Vesicles.Journal of extracellular vesicles · 2026Article
- Tissue localization of natural killer cells dictates surveillance of lung metastasis.Nature communications · 2025Article
- Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement.Nutrition & metabolism · 2025Review
- Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions.International journal of molecular sciences · 2025Article
- Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles.Frontiers in immunology · 2025Article
- Identification of Estrogen-Responsive Proteins in Mouse Seminal Vesicles Through Mass Spectrometry-Based Proteomics.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors.Frontiers in immunology · 2024Article
- A Phase I Single-Arm Study of Biweekly NHS-IL12 in Patients With Metastatic Solid Tumors.The oncologist · 2023Article
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.The Journal of experimental medicine · 2022Article
- Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.The Journal of experimental medicine · 2022Article
- Interleukin-15 in Outcomes of Pregnancy.International journal of molecular sciences · 2021Review
- Implications of a 'Third Signal' in NK Cells.Cells · 2021Review
- Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.Journal of cellular and molecular medicine · 2021Article
- Article
- NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and ChronicFrontiers in cellular and infection microbiology · 2020Article
- Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice.World journal of microbiology & biotechnology · 2019Article
- Tree-ensemble analysis assesses presence of multifurcations in single cell data.Molecular systems biology · 2019Article
- On the Way to Become a Natural Killer Cell.Frontiers in immunology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (γc)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted γc deletion. Herein we identify an alternative pathway of NK-cell development driven by the proinflammatory cytokine IL-12, which can occur independently of γc-signalling. In response to viral infection or upon exogenous administration, IL-12 is sufficient to elicit the emergence of a population of CD122
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.