ReviewEpigenomics2017
Epigenetics, obesity and early-life cadmium or lead exposure.
Review in Epigenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Pooled it
- Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity.Physiological genomics · 2025Trial
- Associations of occupational exposure to multiple heavy metals and metabolic syndrome among metal foundry workers: a cross‑sectional study.BMC endocrine disorders · 2026Article
- Endocrine-disrupting properties of heavy metal exposure contribute to the intergenerational effects on learning and memory.Frontiers in endocrinology · 2026Review
- As, Cd, Hg, and Pb Biological Concentrations and Anthropometry in Slovak Adolescents.Biological trace element research · 2025Article
- Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- DNA methylation signatures of arsenic exposure and obesity.Environmental epigenetics · 2025Article
- The association between heavy metal exposure and obesity: A systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2024Review
- Family- and neighborhood-level environmental associations with physical health conditions in 9- and 10-year-olds.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches.Toxics · 2023Review
- Article
- The effect of endocrine-disrupting chemicals on placental development.Frontiers in endocrinology · 2023Review
- The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age.Biological trace element research · 2022Article
- Influencing factors of residents' environmental health literacy in Shaanxi province, China: a cross-sectional study.BMC public health · 2022Article
- Association between environmental lead/cadmium co-exposure in drinking water and soil and type 2 diabetes mellitus/obesity in Southern China.Frontiers in public health · 2022Article
- The endocrine disruptor cadmium: a new player in the pathophysiology of metabolic diseases.Journal of endocrinological investigation · 2021Review
- Low‑Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State.Exposure and health · 2021Article
- Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.Environment international · 2020Article
- Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage.International journal of environmental research and public health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Obesity is a complex and multifactorial disease, which likely comprises multiple subtypes. Emerging data have linked chemical exposures to obesity. As organismal response to environmental exposures includes altered gene expression, identifying the regulatory epigenetic changes involved would be key to understanding the path from exposure to phenotype and provide new tools for exposure detection and risk assessment. In this report, we summarize published data linking early-life exposure to the heavy metals, cadmium and lead, to obesity. We also discuss potential mechanisms, as well as the need for complete coverage in epigenetic screening to fully identify alterations. The keys to understanding how metal exposure contributes to obesity are improved assessment of exposure and comprehensive establishment of epigenetic profiles that may serve as markers for exposures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.