Evidence map›Paper›PMID 27981781›Full record

ReviewMolecular nutrition & food research2017

Association between dietary inflammatory index and inflammatory markers in the HELENA study.

Nitin Shivappa, James R Hebert, Ascensión Marcos, Ligia-Esperanza Diaz, Sonia Gomez, Esther Nova, Nathalie Michels, Aline Arouca, Esther González-Gil, Gottrand Frederic and 11 more

Abstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  20. Pro-Inflammatory Dietary Patterns Are Associated With Atopic but Not Non-Atopic Dermatitis in Asian Adults: Evidence From a Cross-Sectional Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article

120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nitin ShivappaCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
James R HebertCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
Ascensión MarcosDepartment of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Madrid, Spain.
Ligia-Esperanza DiazDepartment of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Madrid, Spain.
Sonia GomezDepartment of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Madrid, Spain.
Esther NovaDepartment of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition, Madrid, Spain.
Nathalie MichelsDepartment of Public Health, Ghent University, Ghent, Belgium.
Aline AroucaDepartment of Public Health, Ghent University, Ghent, Belgium.
Esther González-GilGENUD "Growth, Exercise, NUtrition and Development" Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Faculty of Health Sciences Universidad de Zaragoza, Spain.
Gottrand FredericUniv. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, CIC 1403, Centre d'investigation Clinique, Lille, France.
Marcela González-GrossImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF, Technical University of Madrid, Madrid, Spain.
Manuel J CastilloDepartment of Medical Physiology, School of Medicine, University of Granada, Granada, Spain.
Yannis ManiosDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Mathilde KerstingResearch Institute of Child Nutrition Dortmund, University of Bonn, Germany.
Marc J GunterInternational Agency for Research on Cancer, Nutrition and Metabolism Section, Lyon, France.
Stefaan De HenauwDepartment of Public Health, Ghent University, Ghent, Belgium.
Kafatos AntoniosPreventive Medicine and Nutrition Unit, School of Medicine, University of Crete, Crete, Greece.
Kurt WidhalmDepartment of Pediatrics, Division of Clinical Nutrition, Medical University of Vienna, Vienna, Austria.
Denes MolnarDepartment of Pediatrics, University of Pecs, Pecs, Hungary.
Luis MorenoGENUD "Growth, Exercise, NUtrition and Development" Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Faculty of Health Sciences Universidad de Zaragoza, Spain.
Inge HuybrechtsInternational Agency for Research on Cancer, Nutrition and Metabolism Section, Lyon, France.

Funding

Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
NIDDK NIH HHS R44 DK103377World Health Organization 001
6 · The paper itself

Abstract

backgroundPrevious research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study has yet been conducted to explore the association between inflammatory potential of diet and low-grade systemic inflammation among adolescents whose dietary behavior may be different from adults. METHODS AND

resultsWe examine the predictive ability of 24-h recall-derived dietary inflammatory index (DII) scores on inflammation among 532 European adolescents in the HELENA cross-sectional study. The DII is a literature-derived dietary index developed to predict inflammation. The DII was calculated per 1000 calories and was tested against C-reactive protein, ILs-1,2,4,10, TNF-α, ICAM, vascular cell adhesion molecule (VCAM), and IFN-γ. All inflammatory markers had nonnormal distributions and therefore were log transformed. Analyses were performed using multivariable linear regression, adjusting for age, sex, city, BMI, smoking, and physical activity. Pro-inflammatory diet (higher DII scores) was associated with increased levels of various inflammatory markers: TNF-α, IL-1, 2, IFN-γ,  and vascular cell adhesion molecule (b

conclusionThese results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation in adolescents.

Indexed as

DietBiomarkersBody Mass IndexChronic DiseaseC-Reactive ProteinCytokinesExerciseFatty AcidsHumansInflammationLinear ModelsRisk FactorsSugarsBiomarkersC-Reactive ProteinCytokinesFatty AcidsSugarsAdolescentsCross-sectionalDietHELENAInflammation

Identifiers

PMID27981781
PMCPMC5517083

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.