ArticleBJOG : an international journal of obstetrics and gynaecology2017
Hyperemesis gravidarum and long-term mortality: a population-based cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Nausea and Vomiting in Pregnancy: Prevalence, Clinical Characteristics, and Management Findings from a Prospective Italian Multicenter Cohort Study.Life (Basel, Switzerland) · 2026Article
- Association Between Nausea and Vomiting During Pregnancy and Sleep Quality: Mediating Effect of Depressive Symptoms.International journal of general medicine · 2021Article
- Long-term cardiovascular morbidity following hyperemesis gravidarum: A Norwegian nationwide cohort study.PloS one · 2019Article
- Pregnancy complications in Brazilian puerperal women treated in the public and private health systems.Revista latino-americana de enfermagem · 2018Article
- Hyperemesis gravidarum and long-term mortality: a population-based cohort study.BJOG : an international journal of obstetrics and gynaecology · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality.
designPopulation-based cohort study.
settingMedical Birth Registry of Norway (1967-2002) linked to the Cause of Death Registry. POPULATION: Women in Norway with singleton births in the period 1967-2002, with and without HG. Women were followed until 2009 or death.
methodsCox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).
main outcome measuresThe primary outcome was all-cause mortality during follow up. Secondary outcomes were cause-specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).
resultsOf 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person-years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long-term all-cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75-0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84-1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83-1.29), but a lower long-term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75-0.98).
conclusionIn this large population-based cohort study, HG was not associated with an increased risk of long-term all-cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer. TWEETABLE ABSTRACT: Population-based cohort study: Hyperemesis was not associated with an increased risk of long-term mortality.
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