Evidence map›Paper›PMID 27981648›Full record

ArticleExperimental physiology2017

Elevated skin and core temperatures both contribute to reductions in tolerance to a simulated haemorrhagic challenge.

James Pearson, Rebekah A I Lucas, Zachary J Schlader, Daniel Gagnon, Craig G Crandall

Open access · bronzeAbstract read
In one paragraph

Article in Experimental physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

James PearsonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Rebekah A I LucasInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Zachary J SchladerInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Daniel GagnonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Craig G CrandallInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0001-7792-9713
Texas Health Dallas · US

Funding

Exercise in Burn Survivors - Administrative Supplement for EquipmentR01GM068865 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2003 to 2023
$7.0M
HYPERTHERMIA EFFECTS ON HUMAN BAROFLEX FUNCTIONR01HL061388 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 1999 to 2011
$2.4M
NHLBI NIH HHS R01 HL061388NIGMS NIH HHS R01 GM068865
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Combined increases in skin and core temperatures reduce tolerance to a simulated haemorrhagic challenge. The aim of this study was to examine the separate and combined influences of increased skin and core temperatures upon tolerance to a simulated haemorrhagic challenge. What is the main finding and its importance? Skin and core temperatures increase during many occupational settings, including military procedures, in hot environments. The study findings demonstrate that both increased skin temperature and increased core temperature can impair tolerance to a simulated haemorrhagic challenge; therefore, a soldier's tolerance to haemorrhagic injury is likely to be impaired during any military activity that results in increased skin and/or core temperatures. Tolerance to a simulated haemorrhagic insult, such as lower-body negative pressure (LBNP), is profoundly reduced when accompanied by whole-body heat stress. The aim of this study was to investigate the separate and combined influence of elevated skin (T

Indexed as

AdultBody TemperatureFemaleFeverHeat-Shock ResponseHeat Stress DisordersHemorrhageHumansHyperthermia, InducedLower Body Negative PressureMaleSkinSyncopecutaneous vascular conductancehyperthermiasimulated hemmorhagic tolerance

Identifiers

PMID27981648
PMCPMC5784401
OpenAlexW2565569311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.