Evidence map›Paper›PMID 27981440›Full record

ArticleJournal of neurovirology2017

Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status.

Jordan E Lake, Mikhail Popov, Wendy S Post, Frank J Palella, Ned Sacktor, Eric N Miller, Todd T Brown, James T Becker

Abstract read
In one paragraph

Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Obesity and Weight Gain in Persons with HIV.Current HIV/AIDS reports · 2020 · on this map
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan E LakeCenter for Clinical AIDS Research and Education, University of California, Los Angeles, CA, USA. Jordan.E.Lake@uth.tmc.edu.
Mikhail PopovDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Wendy S PostDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Frank J PalellaDepartment of Medicine, Northwestern University, Chicago, IL, USA.
Ned SacktorDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Eric N MillerDepartment of Psychiatry and Bio-behavioral Sciences, University of California, Los Angeles, CA, USA.
Todd T BrownDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
James T BeckerDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8M
Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and CognitionR01AG034852 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 2010 to 2020
$9.2M
Mentoring in Endocrine and Metabolic Abnormalities in HIV and AgingK24AI120834 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T · 2015 to 2025
$1.8M
Inflammation, Fibrosis and End-Organ Disease in HIV-Infected AdultsK23AI110532 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LAKE, JORDAN E · 2014 to 2018
$937k
Magnetoencephalography as a Biomarker for HIV-Associated Neurocognitive DisorderR21MH098745 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 2012 to 2013
$398k
NCATS NIH HHS UL1 TR001079NIAID NIH HHS K23 AI110532NIAID NIH HHS K24 AI120834NIAID NIH HHS P30 AI028697NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS UM1 AI035043NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG034852NIMH NIH HHS R21 MH098745
6 · The paper itself

Abstract

The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133 HIV+, 84 HIV-) in the MACS Cardiovascular 2 and magnetic resonance imaging (MRI) sub-studies with CT-quantified VAT and whole brain MRI measured within 1 year were assessed. Voxel-based morphometry analyzed brain volumes. Men were stratified by elevated (eVAT, ≥100cm

Indexed as

AdiponectinAdiposityBody Mass IndexCross-Sectional StudiesDiabetes MellitusGene ExpressionGray MatterHippocampusHIV InfectionsHumansHypertensionInterleukin-6Intra-Abdominal FatMagnetic Resonance ImagingMaleMiddle AgedAdiponectinADIPOQ protein, humanIL6 protein, humanInterleukin-6Brain atrophyBrain volumeHIVVisceral fat

Identifiers

PMID27981440
PMCPMC5441960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.